Evidence map›Paper›PMID 40908637›Full record

ArticleCell proliferation2026

Soluble Sema4D From γδ T Cells Exerts Osteoblast Inhibition via Plexin-B/mTOR Signalling Contributing to Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaws.

Lingling Ou, Shijia Qiao, Zhuoyi Liao, Xiner Tan, Hui Huang, Zhiyan Zhou, Ruhui Luo, Weijun Zeng, Yan Yang, Zhongxuan Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lingling OuSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China.
Shijia QiaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Zhuoyi LiaoSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China.
Xiner TanStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Hui HuangInstitute of Mass Spectrometry and Atmospheric Environment, Jinan University, Guangzhou, China.
Zhiyan ZhouGuangdong Second Traditional Chinese Medicine Hospital, Guangzhou, China.
Ruhui LuoThe Second Affiliated Hospital of Zhejiang University School of Medicine, Jinan University, Guangzhou, China.
Weijun ZengSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China.
Yan YangSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China.
Zhongxuan ZhangSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China.
Jingchen ChenSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China.
Shengli WangThe Biomedical Translational Research Institute, Jinan University, Guangzhou, China.
Yiqin JiangDepartment of Otolaryngology, Shenzhen Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, China.
Jianlei HaoThe Biomedical Translational Research Institute, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4600-3082
Yuqin ShenSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-1207-3392
Longquan ShaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-3770-0815

Funding

Guangdong Basic and Applied Basic Research Foundation 2021A15012155
6 · The paper itself

Abstract

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication in patients undergoing long-term bisphosphonate therapy, while our knowledge on the pathogenesis of BRONJ is far from sufficient. Gamma delta (γδ) T cells predominantly distribute in mucosal tissues and play an important role in both immune modulation and bone metabolism; however, the mechanism of γδ T cells in the pathogenesis of BRONJ has not been elucidated. Here, we induced BRONJ-like lesions in wild-type (WT) and T-cell receptor delta-deficient (TCRδ

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawNerve Tissue ProteinsOsteoblastsReceptors, Antigen, T-Cell, gamma-deltaSemaphorinsTOR Serine-Threonine KinasesAnimalsAntigens, CDCell DifferentiationIntraepithelial LymphocytesMiceMice, Inbred C57BLMice, KnockoutOsteogenesisSignal TransductionZoledronic AcidAntigens, CDCD100 antigenmTOR protein, mouseNerve Tissue ProteinsReceptors, Antigen, T-Cell, gamma-deltaSemaphorinsTOR Serine-Threonine KinasesZoledronic AcidBRONJgel‐BG@abMMP3Sema4Dγδ T cells

Identifiers

PMID40908637
PMCPMC13052030

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.