Evidence map›Paper›PMID 40908585›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Sono-Controllable Janus Hydrogel Platform for Sequential Tumor Eradication and Bone Regeneration in Metastatic Breast Cancer.

Yitong Li, Yunyun Liu, Chuyun Lou, Xuejun Chen, Ying Zhang, Hui Shi, Jiayi Qiu, Shen Zhang, Taixia Wang, Xiaowei Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yitong LiDepartment of Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Yunyun LiuDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
Chuyun LouDepartment of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan Province, 450052, P. R. China.
Xuejun ChenDepartment of Ultrasound, Zhongshan Hospital (Xiamen), Fudan University, Fujian Province, Xiamen, 361015, P. R. China.
Ying ZhangDepartment of Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Hui ShiDepartment of Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Jiayi QiuDepartment of Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Shen ZhangDepartment of Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Taixia WangDepartment of Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Xiaowei WangDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University Cancer Center, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
Haohao YinDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
Huixiong XuDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.ORCID https://orcid.org/0000-0002-1977-0449
Yifeng ZhangDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China.

Funding

National Natural Science Foundation of China 82171942National Natural Science Foundation of China 82371971
6 · The paper itself

Abstract

Bone metastases occur in 60%-75% of patients with metastatic breast cancer, reducing survival rates and compromising quality of life. Innovative treatments are urgently needed to sequentially eradicate tumor cells and promote bone regeneration. In this study, a novel Janus hydrogel platform (GA@CaMP) is developed for encapsulating the sonosensitive composite nanomaterial MHP, which enables gene expression regulation, along with oxygen-releasing CaO

Indexed as

Bone NeoplasmsBone RegenerationBreast NeoplasmsHydrogelsAnimalsCell Line, TumorFemaleHumansMiceHydrogelsbone metastasesbone regenerationJanus hydrogelnecroptosisreactive oxygen speciestumor eradication

Identifiers

PMID40908585
PMCPMC12631841

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.