Evidence map›Paper›PMID 40908490›Full record

ArticleBioelectronic medicine2025

Multi-system benefits of non-invasive spinal cord stimulation following cervical spinal cord injury: a case study.

Soshi Samejima, Claire Shackleton, Raza N Malik, Ali Hosseinzadeh, Lucas Rempel, Anh-Duong Phan, Alison Williams, Tom Nightingale, Amandeep Ghuman, Stacy Elliott and 6 more

Abstract read
In one paragraph

Article in Bioelectronic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Neural Interfaces for Bioelectronic Medicine.Bioelectronic medicine · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Soshi SamejimaInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada. soshis@uw.edu.
Claire ShackletonInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Raza N MalikInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Ali HosseinzadehInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Lucas RempelInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Anh-Duong PhanInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Alison WilliamsInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Tom NightingaleInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Amandeep GhumanDepartment of Surgery, St. Paul's Hospital, Vancouver, BC, Canada.
Stacy ElliottInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Matthias WalterInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Klaus KroghDepartment of Clinical Medicine, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Michael BergerInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Tania LamInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Rahul SachdevaInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Andrei V KrassioukovInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada. andrei.krassioukov@vch.ca.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Cervical spinal cord injury (SCI) impairs sensorimotor and autonomic functions. We investigated the effects of lumbosacral transcutaneous spinal cord stimulation (tSCS) on urinary bladder, bowel, and sexual function as well as cardiovascular and sensorimotor functions in one individual with chronic clinically motor-complete cervical SCI, 11 years post-injury. Following 30 sessions of lumbosacral tSCS, the individual presented with improved urinary bladder compliance as well as anorectal function in parallel with mitigation of the severity of autonomic dysreflexia during filling cystometry and anorectal manometry. In addition, long-term tSCS improved erectile function and sexual satisfaction. Furthermore, after long-term tSCS, concurrent tSCS enabled voluntary leg movement. This case study demonstrated the multi-system benefits of lumbosacral tSCS, which holds promise for evolving into a clinically viable therapy for restoring both autonomic and motor functions following SCI.

Indexed as

Autonomic dysfunctionMotor functionSpinal cord injuryTranscutaneous spinal cord stimulation

Identifiers

PMID40908490
PMCPMC12412244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.