ArticleWorld journal of surgical oncology2025
Differences in survival outcomes between HER2-low and HER2-zero breast cancer across heterogeneous HR expression patterns: a real-world study.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- HER2 Expression and Axillary Metastasis in Treatment-Naïve Early Breast Cancer.Breast cancer (Dove Medical Press) · 2026Article
- Different association of gBRCA1 and gBRCA2 variants with HER2-low status in invasive breast cancer: findings from a Ukrainian study.Scientific reports · 2025Article
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4 authors.
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Abstract
introductionHER2-negative breast cancers can be further subclassified into HER2-low and HER2-zero subtypes. The DESTINY-Breast04 trial has established HER2-low as a research hotspot, with recent studies indicating superior survival rates in HER2-low patients than HER2-zero patients. The impact of heterogeneous hormone receptor (HR) expression patterns on HER2-negative breast cancer has not been comprehensively investigated. This study explored how varying ER and PR expression patterns affect survival rates in patients with HER2-negative breast cancer.
methodsThis retrospective study comprised 648 HER2-negative breast cancer patients treated at our hospital between 2010 and 2023. Six subgroups were compared, including ER+/PR+/HER2-low, ER+/PR+/HER2-zero, single HR+/HER2-low, single HR/HER2-zero, ER-/PR-/HER2-low, and ER-/PR-/HER2-zero.
resultWith disease-free survival and overall survival as primary endpoints, the cohort included 648 HER2-negative breast cancer patients. Compared to HER2-zero, HER2-low patients showed a higher proportion of ER positivity (q = 0.016). The ER+/PR + group exhibited a higher proportion of HER2-low, lower N stage, lower histological grade, and lower Ki-67% (p < 0.001), and were also more likely to achieve pCR after neoadjuvant therapy. In the overall population, HER2-low exhibited better survival outcomes. Compared to single HR+/HER2-low, ER+/PR+/HER2-low had longer DFS (p < 0.001). HER2-low is an independent prognostic factor for survival outcomes in HER2-negative patients.
conclusionOur findings suggest that HER2-low breast cancer is associated with improved survival outcomes compared to HER2-zero breast cancer. HER2-low breast cancer exhibits different survival outcomes across different HR subgroups. These findings may guide future biomarker-driven treatment strategies in HER2-negative breast cancer.
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