Evidence map›Paper›PMID 40908439›Full record

ReviewBiotechnology letters2025

A functional and applied perspective of Vitreoscilla hemoglobin: from oxygen carriage to biotechnological innovation.

Lianggang Huang, Yurong Li, Zhiqiang Liu, Yuguo Zheng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biotechnology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. EngineeringSynthetic and systems biotechnology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lianggang HuangNational and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China.
Yurong LiNational and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China.
Zhiqiang LiuNational and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China. microliu@zjut.edu.cn.ORCID http://orcid.org/0000-0003-3259-6796
Yuguo ZhengNational and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China.

Funding

National Key Research and Development Program of China 2022YFC2105400National Natural Science Foundation of China 32200054
6 · The paper itself

Abstract

Vitreoscilla hemoglobin (VHb), a homodimeric bacterial hemoglobin, exhibits distinct oxygen-binding properties that enhance cellular respiration and metabolic activity, particularly under hypoxic conditions. This review presents an updated and comprehensive synthesis of VHb-related research, encompassing its molecular structure, redox biochemistry, and transcriptional regulation. Compared with previous reviews, this work integrates recent mechanistic insights-especially those concerning transcription factor interactions, redox-coupled electron transfer, and structural-function relationships elucidated via targeted mutagenesis. In addition to its canonical role in oxygen delivery, VHb has been increasingly utilized in synthetic biology, high-cell-density fermentation, CRISPR-regulated expression platforms, and mammalian systems. Its biotechnological applications extend to enhancing microbial productivity under oxygen limitation, facilitating biocatalysis, and promoting biodegradation. In addition, the review highlights the emerging application of the vgb promoter as a strong regulatory element and summarizes current trends in VHb-related intellectual property and commercial development. VHb also shows promise in next-generation technologies such as environmental remediation and precision agriculture. Future directions should focus on optimizing expression systems, characterizing protein interaction networks, and engineering modular VHb-based components for advanced biosystems.

Indexed as

Bacterial ProteinsBiotechnologyOxygenTruncated HemoglobinsVitreoscillaOxidation-ReductionSynthetic BiologyBacterial Proteinshemoglobin protein, VitreoscillaOxygenTruncated HemoglobinsBiocatalysisBiodegradationBiosynthesisOxidative stressOxygen bindingOxygen transferVitreoscilla hemoglobin

Identifiers

PMID40908439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.