Evidence map›Paper›PMID 40908384›Full record

ArticleInnere Medizin (Heidelberg, Germany)2026

[Rare cause of pure white cell aplasia (PWCA) in a 76-year-old male patient].

Milven Klka, Evita Bothur, Meike Clemens, Christoph Lutz, Jens Chemnitz

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In one paragraph

Article in Innere Medizin (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Milven KlkaKlinik für Innere Medizin - Hämatologie/Onkologie und Palliativmedizin, Ev. Stift St. Martin, Koblenz, Deutschland. milven.klka@gk.de.
Evita BothurMVZ für Laboratoriumsmedizin Koblenz-Mittelrhein, Koblenz, Deutschland.
Meike ClemensKlinik für Innere Medizin - Hämatologie/Onkologie und Palliativmedizin, Ev. Stift St. Martin, Koblenz, Deutschland.
Christoph LutzPraxis für Hämatologie und Onkologie Koblenz, Koblenz, Deutschland.
Jens ChemnitzKlinik für Innere Medizin - Hämatologie/Onkologie und Palliativmedizin, Ev. Stift St. Martin, Koblenz, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pure white cell aplasia (PWCA) is a rare hematological condition characterized by the complete absence of granulocytes and myeloid precursor cells in the bone marrow. In this case report, we describe a 76-year-old patient with chronic lymphocytic leukemia (CLL) and cutaneous squamous cell carcinoma of the right upper eyelid who developed PWCA after treatment with the immune checkpoint inhibitor (ICI) cemiplimab. The PWCA is a rare side effect of checkpoint inhibitors. The exact cause is not fully understood, but it is believed that dysregulation of the immune system triggers the condition. The treatment of PWCA typically involves corticosteroids and granulocyte colony-stimulating factors (G-CSF). In cases of non-response, high-dose intravenous immunoglobulin (IVIg) or cyclosporine can be administered.

Indexed as

Antibodies, Monoclonal, HumanizedCarcinoma, Squamous CellImmune Checkpoint InhibitorsLeukemia, Lymphocytic, Chronic, B-CellSkin NeoplasmsAgedEyelid NeoplasmsGranulocyte Colony-Stimulating FactorHumansMaleAntibodies, Monoclonal, HumanizedGranulocyte Colony-Stimulating FactorImmune Checkpoint InhibitorsCLLCyclosporineImmune checkpoint inhibitor cemiplimabLiver dysfunctionNeutropenia

Identifiers

PMID40908384

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.