Evidence map›Paper›PMID 40908376›Full record

ArticleMarine biotechnology (New York, N.Y.)2025

Onnamides and a Novel Analogue, Onnamide G, as Potent Leishmanicidal Agents.

Takahiro Jomori, Nanami Higa, Trianda Ayuning Tyas, Natsuki Matsuura, Yudai Ueda, Ayumi Suetake, Shin Miyazaki, Shuichi Watanabe, Sei Arizono, Yasuhiro Hayashi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Takahiro JomoriDepartment of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa, 903-0213, Japan. tjomori7@cs.u-ryukyu.ac.jp.
Nanami HigaDepartment of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa, 903-0213, Japan.
Trianda Ayuning TyasDepartment of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa, 903-0213, Japan.
Natsuki MatsuuraFaculty of Pharmaceutical Sciences, Tokyo University of Science, Niijuku, Tokyo, Katushika, 125-8585, Japan.
Yudai UedaFaculty of Pharmaceutical Sciences, Tokyo University of Science, Niijuku, Tokyo, Katushika, 125-8585, Japan.
Ayumi SuetakeFaculty of Pharmaceutical Sciences, Tokyo University of Science, Niijuku, Tokyo, Katushika, 125-8585, Japan.
Shin MiyazakiFaculty of Pharmaceutical Sciences, Tokyo University of Science, Niijuku, Tokyo, Katushika, 125-8585, Japan.
Shuichi WatanabeFaculty of Pharmaceutical Sciences, Tokyo University of Science, Niijuku, Tokyo, Katushika, 125-8585, Japan.
Sei ArizonoFaculty of Agriculture, University of Miyazaki, Gakuen-Kibanadai-Nishi, Miyazaki, Miyazaki, 889-2192, Japan.
Yasuhiro HayashiFaculty of Agriculture, University of Miyazaki, Gakuen-Kibanadai-Nishi, Miyazaki, Miyazaki, 889-2192, Japan.
Ko YasumotoSchool of Marine Biosciences, Kitasato University, Kitasato, Minami, Sagamihara, Kanagawa, 252-0373, Japan.
Yuji IseFaculty of Human Environmental Studies, Hiroshima Shudo University, Ozuka, Asaminami-ku, Hiroshima, 731-3195, Japan.
Toshiyuki WakimotoFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, 060-0812, Japan.
Mina Yasumoto-HiroseTropical Technology Plus, Uruma, Okinawa, 904-2234, Japan.
Junichi TanakaDepartment of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa, 903-0213, Japan.
Kanami Mori-YasumotoFaculty of Pharmaceutical Sciences, Tokyo University of Science, Niijuku, Tokyo, Katushika, 125-8585, Japan. yasumoto@rs.tus.ac.jp.

Funding

AMED JP24nk0101699Okinawa Innovation Eco-System Joint Research Promotion Project FY2022-2024the Japan Society for the Promotion of Science 22K20717
6 · The paper itself

Abstract

Leishmaniasis is a neglected tropical disease posing significant global health challenges. Given the limited effective treatment options and associated constraints, many patients are unable to complete therapy. In this study, we report the remarkable leishmanicidal activity of onnamides derived from the marine sponge Theonella sp. against the promastigote form of Leishmania major (IC

Indexed as

Antiprotozoal AgentsLeishmania majorAmphotericin BAnimalsHep G2 CellsHumansPoriferaStructure-Activity RelationshipAmphotericin BAntiprotozoal AgentsAntileishmanial activityCytotoxicityDiscodermia irregularisLeishmania majorLeishmaniasisOnnamidesTheonella sp.

Identifiers

PMID40908376
PMCPMC12411591

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.