Evidence map›Paper›PMID 40908369›Full record

ArticleNature microbiology2025

Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota.

Takayoshi Fujiwara, Toshiaki Hosaka, Masumi Hasegawa-Takano, Yosuke Nishimura, Kento Tominaga, Kaho Mori, Satoshi Nishino, Yuno Takahashi, Tomomi Uchikubo-Kamo, Kazuharu Hanada and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Protonation-Enhanced Energy Transfer in Xanthorhodopsin Kin4B8.The journal of physical chemistry letters · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Takayoshi Fujiwara *Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Toshiaki Hosaka *Laboratory for Protein Functional and Structural Biology, Center for Biosystems Dynamics Research, RIKEN, Yokohama, Japan.ORCID http://orcid.org/0000-0002-7652-8114
Masumi Hasegawa-TakanoInstitute for Extra-cutting-edge Science and Technology Avant-garde Research, Japan Agency for Marine-Earth Science and Technology, Yokosuka, Japan.ORCID http://orcid.org/0000-0002-4227-8321
Yosuke NishimuraResearch Center for Bioscience and Nanoscience, Japan Agency for Marine-Earth Science and Technology, Yokosuka, Japan.ORCID http://orcid.org/0000-0002-8028-3228
Kento TominagaGraduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.ORCID http://orcid.org/0000-0003-4814-5690
Kaho MoriGraduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.ORCID http://orcid.org/0009-0004-2388-8548
Satoshi NishinoGraduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.ORCID http://orcid.org/0009-0007-2070-7678
Yuno TakahashiGraduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Tomomi Uchikubo-KamoLaboratory for Protein Functional and Structural Biology, Center for Biosystems Dynamics Research, RIKEN, Yokohama, Japan.ORCID http://orcid.org/0000-0003-4331-3923
Kazuharu HanadaLaboratory for Protein Functional and Structural Biology, Center for Biosystems Dynamics Research, RIKEN, Yokohama, Japan.
Takashi MaokaResearch Institute for Production Development, Kyoto, Japan.
Shinichi TakaichiFaculty of Life Sciences, Tokyo University of Agriculture, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1621-9141
Keiichi InoueGraduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan. inoue@issp.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-6898-4347
Mikako ShirouzuLaboratory for Protein Functional and Structural Biology, Center for Biosystems Dynamics Research, RIKEN, Yokohama, Japan. mikako.shirouzu@riken.jp.ORCID http://orcid.org/0000-0002-7997-2149
Susumu YoshizawaGraduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan. yoshizawa@aori.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0001-9667-6010

Funding

Japan Agency for Medical Research and Development (AMED) JP23ama121013MEXT | JST | Core Research for Evolutional Science and Technology (CREST) JPMJCR22N2
6 · The paper itself

Abstract

Microbial rhodopsins are photoreceptor proteins widely distributed in marine microorganisms that harness light energy and support marine ecosystems. While retinal is typically the sole chromophore in microbial rhodopsins, some proteorhodopsins, which are proton-pumping rhodopsins abundant in the ocean, use carotenoid antennae to transfer light energy to retinal. However, the mechanism by which carotenoids enhance rhodopsin functions remains unclear. Here, using the marine Bacteroidota isolate Nonlabens marinus S1-08

Indexed as

BacteroidetesCarotenoidsRhodopsinRhodopsins, MicrobialAquatic OrganismsBacterial ProteinsCryoelectron MicroscopyEnergy TransferLightProtein BindingSeawaterBacterial ProteinsCarotenoidsproteorhodopsinRhodopsinRhodopsins, Microbial

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.