Evidence map›Paper›PMID 40908366›Full record

ArticleNature structural & molecular biology2025

tRNA as an assembly chaperone for a macromolecular transcription-processing complex.

Julia Bartuli, Stefan Jungwirth, Manisha Dixit, Takumi Okuda, Johannes Patrick Zimmermann, Matthias Erlacher, Tao Pan, Asisa Volz, Alexander Hüttenhofer, Bettina Warscheid and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. tRNA modifications in viral replication.The Journal of biological chemistry · 2026
    Review
  2. Article
  3. Closing 2025, and a look ahead.Nature structural & molecular biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julia Bartuli *Department of Biochemistry 1, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany.
Stefan JungwirthDepartment of Biochemistry 1, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany.
Manisha DixitDepartment of Biochemistry 1, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany.
Takumi OkudaInstitute of Organic Chemistry, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-2136-6525
Johannes Patrick ZimmermannDepartment of Biochemistry 2, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-5692-2096
Matthias ErlacherInstitute of Genomics and RNomics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-5570-9437
Tao PanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1096-8405
Asisa VolzUniversity of Veterinary Medicine Hannover (TiHo), Institute of Virology, Hannover, Germany.
Alexander HüttenhoferInstitute of Genomics and RNomics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Bettina WarscheidDepartment of Biochemistry 2, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-5096-1975
Claudia HöbartnerInstitute of Organic Chemistry, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-4548-2299
Clemens Grimm *Department of Biochemistry 1, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany. clemens.grimm@uni-wuerzburg.de.ORCID http://orcid.org/0000-0001-9085-5130
Utz FischerDepartment of Biochemistry 1, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany. utz.fischer@uni-wuerzburg.de.ORCID http://orcid.org/0000-0002-1465-6591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transfer RNAs (tRNAs) are widely recognized for their role in translation. Here, we describe a previously unidentified function of tRNA as an assembly chaperone. During poxviral infection, tRNA

Indexed as

Molecular ChaperonesRNA, TransferTranscription, GeneticCryoelectron MicroscopyDNA-Directed RNA PolymerasesHumansModels, MolecularNucleic Acid ConformationDNA-Directed RNA PolymerasesMolecular ChaperonesRNA, Transfer

Identifiers

PMID40908366
PMCPMC12618233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.