ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025
Effect of intraoperative tranexamic acid on blood loss and outcomes in intertrochanteric fractures: a retrospective study of 1728 patients.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Perioperative Anemia and Transfusion Management in Older Adults with Osteoporotic Hip Fractures: A Narrative Review of Current Evidence and Emerging Strategies.Clinical interventions in aging · 2026Review
- Intraoperative tranexamic acid use in elderly patients with intertrochanteric fractures: impact on early postoperative inflammation and clinical outcomes.Frontiers in physiology · 2026Article
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8 authors.
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Abstract
purposeTo evaluate the effect of intraoperative tranexamic acid (TXA) on perioperative blood loss, transfusion requirements, and clinical outcomes in patients undergoing proximal femoral nailing (PFN) for intertrochanteric fractures.
methodsA retrospective cohort study of 1,728 patients who underwent PFN fixation for intertrochanteric fractures between 2017 and 2024. Perioperative hemoglobin (Hb) dynamics, transfusion requirements, and clinical outcomes were compared between patients receiving 1-1.5 g intravenous TXA (n = 1,446) and controls (n = 282).
resultsThe TXA group demonstrated reduced perioperative Hb decline (2.15 ± 1.40 vs 2.76 ± 1.57 g/dL, p < 0.001) and lower rates of Hb drop > 2 g/dL (47.9% vs 63.5%, OR 0.53, p < 0.001). TXA administration was associated with decreased transfusion requirements (7.1% vs 11.0%, p = 0.021). Multivariate analysis confirmed TXA as an independent protective factor against blood loss. Mortality rates showed no significant difference between groups.
conclusionIntraoperative TXA during PFN fixation was associated with reduced perioperative blood loss and transfusion requirements. These findings support TXA as an effective blood conservation strategy in elderly patients with intertrochanteric fractures.
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