Evidence map›Paper›PMID 40908310›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Dexmedetomidine's effect on neonatal sedation, pain, respiratory status and cardiovascular system.

Marjorie M Makoni, Ivonne Sierra-Strum, Adrianne R Bischoff, Jamie L Miller, Lise DeShea, William Howard Beasley, Edgardo Szyld

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marjorie M MakoniSection of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. marjorie-makoni@ouhsc.edu.ORCID http://orcid.org/0000-0003-1248-5677
Ivonne Sierra-StrumLos Angeles General Medical Center and Children's Hospital Los Angeles, Los Angeles, CA, USA.
Adrianne R BischoffDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-9218-1301
Jamie L MillerDepartment of Pharmacy: Clinical and Administrative Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID http://orcid.org/0000-0003-2637-2550
Lise DeSheaSection of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID http://orcid.org/0000-0003-3232-5216
William Howard BeasleyBiomedical and Behavioral Methodology Core, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Edgardo SzyldSection of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Funding

Addressing Health Disparities among Oklahoma Minority and Rural Communities through Clinical Research Education and Career DevelopmentR25MD011564 · NIMHD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HOUCHEN, COURTNEY WAYNE, STAVRAKIS, STAVROS · 2017 to 2021
$2.7M
NIMHD NIH HHS R25 MD011564U.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health Disparities (NIMHD) R25MD011564
6 · The paper itself

Abstract

objectiveTo describe the effects of dexmedetomidine on sedation, pain, respiratory status, and hemodynamics in neonates.

methodsA retrospective study of 206 infants in a level IV NICU (2016-2021) receiving continuous dexmedetomidine infusion. Pain/sedation scores, BP, vasopressor and inotrope score (VIS), and concomitant sedatives/analgesics (CSA) were recorded before and every 3-4 h for 24 h.

resultsMedian PMA:32 weeks. Hypotension occurred in 26%, primarily in infants <32weeks PMA, correlating with higher VIS and CSA. CSA use significantly predicted vasopressors/inotrope use.

conclusionDexmedetomidine, with CSA, increases cardiovascular instability in preterm infants who have unique myocardial structure and function and therefore higher vulnerability. CLINICAL TRIAL REGISTRATION (IF ANY): None (not applicable).

Indexed as

DexmedetomidineHypnotics and SedativesCardiovascular SystemFemaleHemodynamicsHumansHypotensionInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMalePain MeasurementRetrospective StudiesDexmedetomidineHypnotics and Sedatives

Identifiers

PMID40908310

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.