Evidence map›Paper›PMID 40908266›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2025

Pre- and postnatal maternal depressive symptoms associated with local connectivity of the left amygdala in 5-year-olds.

Elena Vartiainen, Anni Copeland, Elmo P Pulli, Venla Kumpulainen, Eero Silver, Olli Rajasilta, Ashmeet Jolly, Silja Luotonen, Hilyatushalihah K Audah, Niloofar Hashempour and 7 more

Abstract read
In one paragraph

Article in European psychiatry : the journal of the Association of European Psychiatrists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Elena VartiainenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0009-0005-3620-2506
Anni CopelandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-6482-9008
Elmo P PulliFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0003-3871-8563
Venla KumpulainenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0003-3375-5445
Eero SilverFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Olli RajasiltaFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-7524-8217
Ashmeet JollyFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0009-0003-2348-7261
Silja LuotonenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-5226-2286
Hilyatushalihah K AudahFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0009-0003-5437-5561
Niloofar HashempourFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Wajiha BanoFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-0602-5116
Ilkka SuuronenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0009-0001-6516-4116
Ekaterina SaukkoDepartment of Radiology, Turku University Hospital and University of Turku, Turku, Finland.ORCID 0000-0002-2353-2515
Suvi HäkkinenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-6396-1904
Hasse KarlssonFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-4992-1893
Linnea KarlssonFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-4725-0176
Jetro J TuulariFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.ORCID 0000-0002-1797-8000

Funding

Alfred Kordelinin SäätiöEmil Aaltosen SäätiöJane ja Aatos Erkon SäätiöJuho Vainion SäätiöOrionin TutkimussäätiöPäivikki ja Sakari Sohlbergin SäätiöSigne ja Ane Gyllenbergin SäätiöSigrid Juséliuksen SäätiöStrategic Research Council #352648 and subproject #352655Suomen AivosäätiöSuomen KulttuurirahastoSuomen Lääketieteen SäätiöTurun yliopiston tutkijakouluTurun YliopistosäätiöVarsinais-Suomen Sairaanhoitopiiri
6 · The paper itself

Abstract

backgroundMaternal depressive symptoms can influence brain development in offspring, prenatally through intrauterine programming, and postnatally through caregiving related mother-child interaction.

methodsThe participants were 5-year-old mother-child dyads from the FinnBrain Birth Cohort Study (

resultsWe found that maternal depressive symptoms were positively associated with ReHo values of the left amygdala. The association was highly localized and strongest with the maternal depressive symptoms at 3 months postnatal. Seed-based connectivity analysis did not reveal associations between distal connectivity of the left amygdala region and maternal depressive symptoms.

conclusionsThese results suggest that maternal depressive symptoms soon after birth may influence offspring's neurodevelopment in the local functional coherence in the left amygdala. They underline the potential relevance of postnatal maternal distress exposure on neurodevelopment that has received much less attention than prenatal exposures. These results offer a possible thus far understudied pathway of intergenerational effects of perinatal depression that should be further explored in future studies.

Indexed as

AmygdalaDepressionDepression, PostpartumMother-Child RelationsMothersAdultChild, PreschoolFemaleHumansMagnetic Resonance ImagingMalePregnancyamygdalafMRImaternal depressionneurodevelopmentReHo

Identifiers

PMID40908266
PMCPMC12538180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.