Evidence map›Paper›PMID 40908256›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Mitochondrial diagnostics reveal diffuse impairments in skeletal muscle energetics in aging mice.

Keon D Wimberly, Mia Y Kawaida, Abigail L Tice, Xiaoping Luo, Jacob A Lackey, Samuel Alvarez, Lan Wei-LaPierre, Russell T Hepple, Terence E Ryan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keon D WimberlyDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.
Mia Y KawaidaDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.
Abigail L TiceDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.
Xiaoping LuoDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.
Jacob A LackeyDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.
Samuel AlvarezDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.
Lan Wei-LaPierreDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-4781-5886
Russell T HeppleDepartment of Physical Therapy, University of Florida, Gainesville, Florida, United States.ORCID 0000-0003-3640-486X
Terence E RyanDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States.ORCID 0000-0003-0780-029X

Funding

Linking kynurenine accumulation and the AHR pathway to exacerbated agingR01AG076490 · NIA · UNIVERSITY OF FLORIDA · PI Russell T Hepple, Terence E Ryan · 2022 to 2026
$2.5M
Translational Research Training on Aging and Mobility (TRAM)T32AG062728 · NIA · UNIVERSITY OF FLORIDA · PI Todd Manini · 2020 to 2026
$2.0M
Targeting muscle kynurenine aminotransferases and the AHR pathway to mitigate age-related physical declineF32AG087637 · NIA · UNIVERSITY OF FLORIDA · PI WIMBERLY, KEON · 2024 to 2025
$131k
HHS | NIH | National Institute on Aging (NIA) F32-AG087637HHS | NIH | National Institute on Aging (NIA) R01-AG076490HHS | NIH | National Institute on Aging (NIA) T32-AG062728NIA NIH HHS F32 AG087637NIA NIH HHS R01 AG076490NIA NIH HHS T32 AG062728
6 · The paper itself

Abstract

Aging is associated with progressive declines in skeletal muscle mass, strength, and endurance, often linked to mitochondrial dysfunction. However, a complete understanding of mitochondrial impairments during aging is lacking. Herein, we examined how biological sex and aging affect muscle function and mitochondrial energy transduction. Male and female C57BL/6 mice at 16 and 26 mo of age (

Indexed as

AgingEnergy MetabolismMitochondria, MuscleMuscle, SkeletalAnimalsFemaleMaleMiceMice, Inbred C57BLMuscle ContractionMuscle StrengthOxidation-ReductionOxygen Consumptionagingmetabolismmitochondriamuscle

Identifiers

PMID40908256
PMCPMC12501862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.