Evidence map›Paper›PMID 40908115›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025

Integrated muscle protein synthesis during disuse and rehabilitation in late-midlife adults.

Sean P Kilroe, Zachary D Von Ruff, Hanna Kalenta, Vladislav Bugay, Emily J Arentson-Lantz, Andrew J Murton, Victoria G Rontoyannni, Doaa Reda Abdelrahman, Elena Volpi, Douglas Paddon-Jones and 1 more

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sean P KilroeDepartment of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.ORCID 0009-0000-9382-3783
Zachary D Von RuffDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States.
Hanna KalentaDepartment of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.ORCID 0009-0000-7965-4733
Vladislav BugayDepartment of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.
Emily J Arentson-LantzDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States.ORCID 0000-0001-7303-8067
Andrew J MurtonDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States.
Victoria G RontoyannniDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States.ORCID 0000-0002-6608-496X
Doaa Reda AbdelrahmanDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States.
Elena VolpiBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.ORCID 0000-0001-8776-0384
Douglas Paddon-JonesDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States.
Blake B RasmussenDepartment of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.ORCID 0000-0001-7854-5375

Funding

UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
San Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Elena Volpi · 2015 to 2026
$14.1M
Sex-specific determinants of early-phase recovery from skeletal muscle disuse.R01AG064386 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RASMUSSEN, BLAKE B · 2019 to 2022
$2.0M
HHS | NIH | National Institute on Aging (NIA) P30 AGO24832HHS | NIH | National Institute on Aging (NIA) R01 AG064683NIA NIH HHS P30 AG024832NIA NIH HHS P30 AG044271NIA NIH HHS R01 AG064386
6 · The paper itself

Abstract

The purpose of this study was to investigate the sex-specific differences in how late-midlife adults respond to short-term disuse and rehabilitation. Sixteen late-midlife adults, who were free of overt disease (8 males: 58 ± 2 yr, BMI 29.4 ± 0.8 kg·m

Indexed as

Muscle ProteinsMuscular AtrophyProtein BiosynthesisQuadriceps MuscleFemaleHindlimb SuspensionHumansMaleMechanistic Target of Rapamycin Complex 1Middle AgedMuscle, SkeletalMuscle StrengthSex FactorsMechanistic Target of Rapamycin Complex 1Muscle Proteinsdisuse-atrophymuscle protein synthesisrehabilitationsex differenceskeletal muscle

Identifiers

PMID40908115
PMCPMC12579554

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.