ArticleAmerican journal of physiology. Heart and circulatory physiology2025
Don't go vaping my heart: e-cigarette exposure during pregnancy promotes peripartum ventricular arrhythmias and sympathetic dominance.
Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Influence of Cooling Agents on the Arrhythmogenic and Autonomic Effects of Electronic Cigarettes in an in vivo Model.Circulation. Arrhythmia and electrophysiology · 2026Article
- Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026Review
- Vaping during pregnancy and maternal, fetal, and infant health outcomes: A scoping review of human and animal studies.PloS one · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Electronic cigarettes (e-cigs) are commonly presumed as a safer alternative to traditional cigarettes despite limited understanding of their health risks. This assumption may lead people, especially those in at-risk groups, to switch from traditional cigarettes to e-cigs or to use e-cigs as their first form of nicotine consumption. Despite that pregnancy increases susceptibility to adverse cardiac events, a considerable fraction of pregnant women use e-cigs during gestation and postpartum. Pregnancy involves profound physiological changes that increase the risk for developing cardiac arrhythmias, disruptions in the normal rhythm of the heart that can promote ventricular fibrillation, cardiomyopathy, and sudden cardiac death. In addition, studies have shown that e-cig aerosols can induce sympathetic nervous system dominance and evoke arrhythmias in mice. We posited that e-cig exposure during pregnancy destabilizes maternal cardiac autonomic modulation and induces ventricular arrhythmias. Using radiotelemetry, we found that gestational e-cig exposure accentuates pregnancy-associated sympathetic dominance and increases ventricular premature beats (VPBs) during the parturition period. In addition, at 3 wk postpartum (3 wk after exposure cessation), e-cig-exposed dams have more VPBs, shortened ventricular repolarization, and increased ejection fraction. Therefore, e-cig use during gestation promotes sympathetic dominance and ventricular arrhythmias during parturition. Importantly, these arrhythmias persist up to 3 wk after cessation of exposure and parturition and are accompanied by accelerated repolarization and enhanced left ventricular systolic function consistent with sympathetic dominance. Thus, vaping during pregnancy may increase the incidence of peripartum arrhythmias, with these effects persisting well after e-cig cessation and accompanied by enhanced ventricular repolarization and systole.
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