Evidence map›Paper›PMID 40908027›Full record

ArticleInfluenza and other respiratory viruses2025

Economic Burden of Respiratory Viruses in Latin America and the Caribbean (LAC): A Scoping Literature Review.

Nelson J Alvis-Zakzuk, Paula Couto, Jorge H Jara, Miguel Descalzo, Marc Rondy, Stefano Tempia, Andrea Vicari

Abstract readScoping Review
In one paragraph

Article in Influenza and other respiratory viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nelson J Alvis-ZakzukPan-American Health Organization, Washington, DC, USA.ORCID 0000-0001-9382-214X
Paula CoutoPan-American Health Organization, Washington, DC, USA.
Jorge H JaraPan-American Health Organization, Washington, DC, USA.
Miguel DescalzoPan-American Health Organization, Washington, DC, USA.
Marc RondyPan-American Health Organization, Washington, DC, USA.
Stefano TempiaPartnership for International Vaccine Initiative, Taskforce for Global Health, Atlanta, Georgia, USA.ORCID 0000-0003-4395-347X
Andrea VicariPan-American Health Organization, Washington, DC, USA.

Funding

World Health Organization
6 · The paper itself

Abstract

objectiveThe objective of this study is to summarize the state of knowledge on the economic burden and cost of illness due to influenza, SARS-CoV-2, respiratory syncytial virus (RSV), and other respiratory viruses (ORV) in Latin America and the Caribbean (LAC).

methodsWe performed a scoping review across three databases (PubMed-Medline, Scielo, and Embase) without time restriction, including economic burden and cost-of-illness studies. We extracted and analyzed data on publication year, population, study type, perspective, costing techniques, and settings. We reported absolute and relative frequencies to summarize the results. Economic burden estimates were divided by the gross domestic product (GDP) for each country. Costs were converted into 2022 international dollars (PPP).

resultsOverall, 2638 articles were retrieved; we included 44 full texts from 16 LAC countries. Twenty-four (54.5%) studies focused on influenza, 16 (36.4%) on SARS-CoV-2, 3 (6.8%) on RSV, and 1 on ORV. Twenty two (50.0%) focused on cost-effectiveness (related to vaccination)/cost-benefit analysis, and 17 (38.6%) focused on cost of illness. Most studies (n = 33, 75.0%) were conducted from the third-party perspective. Fifty percent of the studies used a bottom-up costing technique and 29.6% top-down. Influenza direct medical costs ranged from I$6.6-I$300.3 for outpatients and I$62.8-I$222,920 for inpatients; for RSV from I$68.3-I$1292; and for SARS-CoV-2 between I$69.9 and I$38,039. The total annual costs of the influenza economic burden ranged between 0.0003% and 1.33% of the GDP.

conclusionThis study showed variability in costing methods, perspectives, and types of studies among LAC countries. This variability underscores the need for standardized methodologies in future cost studies to ensure comparability and reliability of results.

Indexed as

Cost of IllnessCOVID-19Respiratory Tract InfectionsCaribbean RegionHumansInfluenza, HumanLatin AmericaRespiratory Syncytial Virus InfectionsSARS-CoV-2economic burdeninfluenzaLMICRSVSARS‐CoV‐2

Identifiers

PMID40908027
PMCPMC12411011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.