Evidence map›Paper›PMID 40907998›Full record

ArticleJournal for immunotherapy of cancer2025

The spontaneous neoantigen-specific CD4

Ryan Q Griswold, Spencer E Brightman, Karla Soria Zavala, Manuel Azaid Ordaz-Arias, Navid Djassemi, Rukman R Thota, Martin S Naradikian, Hannah Dose, Suzie Alarcon, Pandurangan Vijayanand and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The spontaneous neoantigen-specific CD4Journal for immunotherapy of cancer · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ryan Q GriswoldUniversity of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0009-0001-8794-8675
Spencer E BrightmanUniversity of California San Diego, La Jolla, California, USA.
Karla Soria ZavalaCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, California, USA.
Manuel Azaid Ordaz-AriasCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, California, USA.
Navid DjassemiUniversity of California San Diego, La Jolla, California, USA.
Rukman R ThotaCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, California, USA.
Martin S NaradikianCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, California, USA.
Hannah DoseAUGenomics Pty Ltd, San Diego, California, USA.
Suzie AlarconAUGenomics Pty Ltd, San Diego, California, USA.
Pandurangan VijayanandLa Jolla Institute for Immunology, La Jolla, California, USA.
Bjoern PetersCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, California, USA.
Aaron M MillerCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, California, USA.
Ezra E W CohenDivision of Hematology and Oncology, UC San Diego Health Moores Cancer Center, La Jolla, California, USA.
Stephen P SchoenbergerCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, California, USA sps@lji.org.ORCID http://orcid.org/0000-0002-9870-7340

Funding

Stimulating Neo-Antigen Specific T Cell Responses in Head and Neck CancersU01DE028227 · NIDCR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI GUTKIND, JORGE SILVIO, RAO, ANJANA · 2018 to 2022
$4.6M
NIDCR NIH HHS U01 DE028227
6 · The paper itself

Abstract

backgroundCD4

methodsWe used a tetramer specific for a validated neoantigen, CTLC

resultsWe find that the natural CD4

conclusionsThese findings offer unprecedented insight into the functional diversity of a natural neoantigen-specific CD4

Indexed as

Antigens, NeoplasmCD4-Positive T-LymphocytesAnimalsHumansMicePhenotypeAntigens, NeoplasmAdoptive cell therapy - ACTCombination therapyImmunotherapyIntratumoralT cell

Identifiers

PMID40907998
PMCPMC12414154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.