Evidence map›Paper›PMID 40907840›Full record

ReviewFree radical biology & medicine2025

Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADP

Leah E Jamerson, Patrick C Bradshaw

Abstract readReview
In one paragraph

Review in Free radical biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Leah E JamersonDepartment of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614, United States. Electronic address: jamersonl@etsu.edu.
Patrick C BradshawDepartment of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614, United States. Electronic address: bradshawp@etsu.edu.

Funding

Testing the NADPH redox theory of aging in C. elegansR15AG059096 · NIA · EAST TENNESSEE STATE UNIVERSITY · PI BRADSHAW, PATRICK CHRISTOPHER · 2018 to 2018
$423k
NIA NIH HHS R15 AG059096
6 · The paper itself

Abstract

Dietary restriction (DR), which slows aging, increases the ratio of reduced glutathione (GSH) to oxidized glutathione disulfide (GSSG) in the brain. DR increases liver cytoplasmic [NADPH]/[NADP

Indexed as

AgingBrainCaloric RestrictionNADPNeuronsAnimalsAstrocytesGlutathioneHumansMiceGlutathioneNADPAgingAstrocyteDietary restrictionFolate cycleNADPHPentose phosphate pathway

Identifiers

PMID40907840
PMCPMC12671688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.