ArticleJournal of the American Chemical Society2025
Bifunctional Catalysis of Aldol Reactions by Foldamer Dihydrazides: Assessment of Conformational Preorganization.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Bifunctional Catalysis of a Crossed Aldol Condensation by Diamines: Impact of Tether Composition and Length.The Journal of organic chemistry · 2026Article
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Authors and funding
5 authors.
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Abstract
We previously reported that molecules containing two cyclic hydrazide units connected by a polymethylene linker could catalyze aldol condensations via a bifunctional mechanism. One hydrazide apparently provides nucleophilic activation, via enamine formation, while the other provides electrophilic activation, via iminium formation. Here, we ask whether catalytic efficacy can be enhanced by using a conformationally preorganized linker to connect the hydrazide units. In the new catalyst series, the linkers are α/β-peptides (oligomers containing α- and β-amino acid residues). The α/β-peptide scaffold features a 1:2 α:β backbone repeat and forms a helix with approximately three residues per turn. When α residues with hydrazide-containing side chains have an
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