Evidence map›Paper›PMID 40907682›Full record

ArticleEnvironmental research2025

Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood.

Sidsel Dan Hull, Kelly K Ferguson, Stephanie J London, Karin Sørig Hougaard, Christian Lindh, Kajsa Ugelvig Petersen, Esben Meulengracht Flachs, Lauren A Wise, Allen J Wilcox, Zeyan Liew and 4 more

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Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sidsel Dan HullDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark. Electronic address: Sidsel.dan.hull@regionh.dk.
Kelly K FergusonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
Stephanie J LondonImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA.
Karin Sørig HougaardDepartment of Public Health, University of Copenhagen, Denmark; National Research Center for the Working Environment, Denmark.
Christian LindhDivision of Occupational and Environmental Medicine, Lund University, Sweden.
Kajsa Ugelvig PetersenDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark.
Esben Meulengracht FlachsDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, USA.
Allen J WilcoxEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
Zeyan LiewDepartment of Environmental Health Sciences, Yale School of Public Health, USA.
Cecilia Høst Ramlau-HansenDepartment of Public Health, Aarhus University, Denmark.
Gunnar ToftSteno Diabetes Center Aarhus, Aarhus University Hospital, Denmark.
Jens Peter BondeDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark; Department of Public Health, University of Copenhagen, Denmark.
Sandra Søgaard TøttenborgDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark; Department of Public Health, Section of Environmental Health, University of Copenhagen, Denmark.

Funding

Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

backgroundPrenatal exposure to per- and polyfluoroalkyl substances (PFAS) may influence lung and immune system development, but previous epidemiological studies are inconclusive and have not extended into young adulthood.

objectiveTo examine associations between prenatal exposure to a mixture of PFAS and respiratory and immune-related outcomes in a cohort of males.

methodsWe studied 866 males with maternal pregnancy plasma measured for 15 PFAS, triclosan, and 10 phthalate metabolites used as a proxy for prenatal exposure. Spirometry was measured at approximately age 19 years. Asthma in young adulthood was reported in questionnaires at age 18 years. Asthma, hay fever, and eczema at 7 and 11 years of age were based on parental reports. We estimated the difference in spirometry measures and odds ratios (ORs) for questionnaire outcomes per one-interquartile range (IQR) increase in a mixture of seven well-detected PFAS using quantile g-computation models. Subsequently, we examined a mixture of seven PFAS, two phthalate metabolites and triclosan, and ran single-pollutant analyses.

resultsA one-IQR increase in the PFAS mixture was associated with lower forced expiratory volume in 1 second (FEV

conclusionPrenatal PFAS exposure was associated with lower FEV

Indexed as

Environmental ExposureFluorocarbonsPrenatal Exposure Delayed EffectsAdolescentAdultChildCohort StudiesEnvironmental PollutantsEnvironmental PollutionFemaleHumansLungMaleMaternal ExposurePhthalic AcidsPregnancyEnvironmental PollutantsFluorocarbonsPhthalic AcidsTriclosanChemical mixtureDNBCFEPOSImmune-related outcomesPhthalate metabolitesQuantile g-computationSpirometryTriclosan

Identifiers

PMID40907682
PMCPMC12451454

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.