ReviewBiological psychiatry2026
CUT&RUN as a Powerful Tool for Chromatin Profiling: A Focus on Neuropsychiatric Disorders.
Review in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Proper regulation of gene expression involves a complex array of crosstalk between chromatin remodeling, histone and DNA modifications, and transcription factors. Dysregulation of these processes is implicated in a wide range of neuropsychiatric conditions. Methods to interrogate transcription factors and epigenomic profiles have revolutionized our ability to study molecular mechanisms in the brain. However, as our understanding of this highly complex system has grown, so has the need for more sophisticated methodology to disentangle such multifaceted and cooperative mechanisms. In this review, we briefly introduce techniques to profile chromatin accessibility, transcription factor regulation, and epigenetic mechanisms, as well as a more recently emerging technique, CUT&RUN (cleavage under targets and release using nuclease), and its role in providing new insights into our understanding of the molecular underpinnings of neuropsychiatric disorders, with a focus on addiction and depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.