Evidence map›Paper›PMID 40907346›Full record

ArticleMultiple sclerosis and related disorders2025

Understanding use and predictors of compensatory cognitive strategies in people with multiple sclerosis.

Jeeyeon Kim, Susan L Murphy, Libak Abou, Kevin N Alschuler, Dawn M Ehde, Nora E Fritz, Anna L Kratz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Jeeyeon KimDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA. Electronic address: jeeyeonk@med.umich.edu.
Susan L MurphyDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Rheumatology Division, University of Michigan, Ann Arbor, MI, USA.
Libak AbouDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.
Kevin N AlschulerDepartment of Rehabilitation Medicine, University of Washington, Seattle, WA, USA; Department of Neurology, University of Washington, Seattle, WA, USA.
Dawn M EhdeDepartment of Rehabilitation Medicine, University of Washington, Seattle, WA, USA.
Nora E FritzDepartments of Health Care Sciences and Neurology, Wayne State University, Detroit, MI, USA; Department of Neurology, Wayne State University, Detroit, MI, USA.
Anna L KratzDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.

Funding

Optimizing detection and prediction of changes in cognitive function in multiple sclerosis with novel ambulatory assessment methodsR01HD102337 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRITZ, NORA E., KRATZ, ANNA LOUISE · 2021 to 2025
$3.0M
NICHD NIH HHS R01 HD102337
6 · The paper itself

Abstract

backgroundCognitive impairment is common in multiple sclerosis (MS) and affects daily functioning. Compensatory cognitive strategies can help mitigate these challenges, but their naturalistic use and predictors remain unclear. This study aimed to examine the frequency and types of strategies used and to determine whether demographics, objective cognitive function, or perceived cognitive function are independently associated with the use of compensatory strategies.

methodsA secondary analysis of baseline data from 268 people with MS was conducted. Compensatory cognitive strategy use was assessed via the Compensatory Cognitive Strategies Scale, perceived cognitive function via the PROMIS Cognitive Function Abilities Short Form, and objective cognitive function via the NIH Toolbox Cognitive Battery. Descriptive statistics characterized compensatory strategy use. A hierarchical linear regression analysis was performed to identify significant predictors of compensatory cognitive strategy use.

resultsParticipants (mean age = 50.8 ± 11.9 years, 77.2 % female) most frequently used electronic reminders (86.6 %), established routines (83.6 %), and broke tasks into smaller steps (84.7 %), while work-related strategies were the least utilized. Lower perceived cognitive function (β = -0.232, p < .01) and walking disability (β = 0.182, p < .01) were significantly associated with greater compensatory strategy use.

conclusionsPerceived cognitive function, rather than objective cognitive function, was associated with compensatory cognitive strategy use. Neuropsychological assessments should identify individuals who are cognitively impaired, especially those unaware of their deficits, to provide guidance on effective strategies. Future research should evaluate compensatory cognitive strategy training to improve long-term functional independence in MS.

Indexed as

CognitionCognitive DysfunctionMultiple SclerosisAdultAgedFemaleHumansMaleMiddle AgedNeuropsychological TestsCognitive functionCompensatory cognitive strategyMultiple sclerosisNeuropsychological tests

Identifiers

PMID40907346
PMCPMC12543356

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.