Evidence map›Paper›PMID 40907163›Full record

ArticleJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2025

Utilizing T1-weighted MRI intensity indices to evaluate in-vivo neurotoxicity in a South African cohort with environmental manganese exposure.

Susan R Criswell, Irene Faust, Susan Searles Nielsen, Wendy W Dlamini, Gill Nelson, Jay R Turner, Joshua S Shimony, Jason Lenox-Krug, Jordan A Killion, T Noah Hutson and 1 more

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Article in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Susan R CriswellDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: susan.criswell@barrowneuro.org.
Irene FaustDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
Susan Searles NielsenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Wendy W DlaminiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Gill NelsonSchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Jay R TurnerDepartment of Energy, Environmental, and Chemical Engineering, Washington University, St. Louis, MO, USA.
Joshua S ShimonyMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Jason Lenox-KrugDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Jordan A KillionDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
T Noah HutsonDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
Brad A RacetteDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.

Funding

WILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI BURBACHER, THOMAS M · 1987 to 2021
$51.2M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Project: Predicting PhenoconversionU19AG071754 · NIA · WASHINGTON UNIVERSITY · PI Bradley F Boeve, Yo-El S Ju · 2021 to 2026
$41.2M
Ethno-epidemiology of HCV, HIV and Overdose associated with Drug Marketsand Drug TourismR01DA049644 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STRATHDEE, STEFFANIE A. · 2020 to 2024
$8.2M
Augmented Neurosurgical Navigation Software Using Resting State MRIR01CA203861 · NCI · WASHINGTON UNIVERSITY · PI Eric CLAUDE Leuthardt, JOSHUA S SHIMONY · 2017 to 2026
$5.8M
Imaging Biomarkers of Neurotoxicity in WeldersR01ES021488 · NIEHS · WASHINGTON UNIVERSITY · PI Brad A Racette · 2013 to 2026
$5.3M
Women and HIV: Translation of Research into Practice-WLHIV Post-Graduate Research FellowshipD43TW009783 · FIC · UNIVERSITY OF WASHINGTON · PI Elizabeth Anne BUKUSI, CAREY FARQUHAR · 2015 to 2026
$4.1M
Motor and Cognitive Health Outcomes in a Mn-Exposed African CommunityR01ES025991 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2015 to 2019
$3.7M
Manganese-Induced Neurotoxic Effects Research in South Africa (MINERS)R01ES026891 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2017 to 2021
$3.3M
NOVEL PET MARKERS OF COGNITIVE IMPAIRMENT IN MANGANESENEUROTOXICITYR01ES029524 · NIEHS · WASHINGTON UNIVERSITY · PI CRISWELL, SUSAN · 2019 to 2023
$3.3M
Epidemiology of Parkinsonism in WeldersR01ES013743 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2007 to 2011
$2.6M
Optimizing HIV prevention portfolios targeting people who inject drugs using dynamic economic modelingR01AI147490 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARTIN, NATASHA · 2019 to 2022
$2.3M
FIC NIH HHS D43 TW009783NCI NIH HHS R01 CA203861NCRR NIH HHS UL1 RR024992NIAID NIH HHS R01 AI147490NIA NIH HHS U19 AG071754NIDA NIH HHS R01 DA049644NIEHS NIH HHS K01 ES028295NIEHS NIH HHS K23 ES021444NIEHS NIH HHS K24 ES017765NIEHS NIH HHS P42 ES004696NIEHS NIH HHS R01 ES013743NIEHS NIH HHS R01 ES021488NIEHS NIH HHS R01 ES025991NIEHS NIH HHS R01 ES026891NIEHS NIH HHS R01 ES029524NIEHS NIH HHS R01 ES030937NIEHS NIH HHS R01 ES035388NINDS NIH HHS R01 NS129643NINDS NIH HHS R41 NS132627NIOSH CDC HHS R01 OH011661
6 · The paper itself

Abstract

backgroundExcessive exposure to manganese (Mn) causes parkinsonism. Occupational Mn exposure is associated with increased T1-weighted globus pallidus signal on magnetic resonance imaging (MRI) secondary to in-vivo Mn deposition.

methodsThe present study evaluated the T1-weighted pallidal index (PI) as an in-vivo marker of Mn exposure and neurotoxicity in chronic environmental Mn exposure. A total of 53 Black South African participants with a range of residential environmental Mn exposures due to proximity to one of the world's largest smelters underwent T1-weighted MRI.

resultsThe PI was associated with parkinsonism as measured by the total Unified Parkinson's Disease Rating Scale motor subsection part 3 (UPDRS3) in all participants (β=0.10, confidence interval 0.01, 0.18). Further, the PI was positively associated with total UPDRS3 scores (β=0.14, confidence interval 0.03, 0.25) and the lower limb rigidity subscore (β=0.04, confidence interval 0.005, 0.07) among those who regularly consumed alcohol (>3 drinks/week), but not in those who occasionally consumed alcohol (<3 drinks/week).

conclusionOur findings suggest T1-weighted PI is associated with clinical neurotoxicity in environmental Mn exposure. This association is amplified by regular consumption of alcohol.

Indexed as

Environmental ExposureMagnetic Resonance ImagingManganeseNeurotoxicity SyndromesAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedSouth AfricaManganeseBiomarkerManganeseMRINeurotoxicology

Identifiers

PMID40907163
PMCPMC12479054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.