Evidence map›Paper›PMID 40906911›Full record

ArticleJournal of pediatric hematology/oncology2025

Hematologic Variations in Children With Down Syndrome.

Golda Grinberg, Gwen Sokoloff, Beverly Hay, Stefanie Lowas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric hematology/oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Golda GrinbergChildren's Medical Center, University of Texas Southwestern Medical Center, Dallas, TX.
Gwen SokoloffDepartment of Pediatrics, Division of Genetics, UMass Chan Medical School and UMass Memorial Children's Medical Center.
Beverly HayDepartment of Pediatrics, Division of Genetics, UMass Chan Medical School and UMass Memorial Children's Medical Center.
Stefanie LowasDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, UMass Chan Medical School and UMass Memorial Children's Medical Center, Worcester, MA.ORCID 0009-0003-0638-0964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematologic abnormalities in children with Down Syndrome (DS) have previously been described, but with inconsistent conclusions. A retrospective single-institution cohort study was conducted to evaluate complete blood count (CBC) ranges in children with DS. Mean values for CBC results are presented by age and sex, as a clinical resource for the evaluation of DS children. In comparison to reference values, children with DS had higher mean corpuscular volume (MCV), lower absolute lymphocyte count, and a trend toward higher hemoglobin (Hgb) values. The presence of these findings across the cohort suggests that these are benign hematologic variations in DS.

Indexed as

blood countdown syndromehemoglobinlymphocytemean corpuscular volume

Identifiers

PMID40906911
PMCPMC12459140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.