ArticleScience (New York, N.Y.)2025
Lewy body dementia promotion by air pollutants.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta-Analysis.Annals of clinical and translational neurology · 2026Pooled it
- IL-17 Signaling Pathway: A Potential Signaling Pathway Mediating Neuroinflammation Induced by PMEnvironment & health (Washington, D.C.) · 2026Article
- Brain-first and body-first subtypes of Lewy body disease.Nature reviews. Neurology · 2026Review
- Quantifying Olfactory and Alveolar Deposition of Ultrafine Particles Using Multiscale Modeling: Implications for Brain Exposure.Environmental science & technology · 2026Article
- DYRK1A and Parkinson's disease, facts and hypotheses.Neurobiology of disease · 2026Review
- Surface cues shape procoagulant properties of amyloidogenic microclots.Cell death & disease · 2026Review
- Exposure to Air Pollutants and Lewy Body and Parkinson Disease-Related Dementias.JAMA network open · 2026Article
- Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Long-Term Exposure to Ambient Air Pollution and Incident Amyotrophic Lateral Sclerosis: A Prospective Cohort Analysis of the UK Biobank.Neurology · 2026Article
- Incense Aerosol-Induced Neurotoxicity Disrupts α-Synuclein Homeostasis in a Cellular Parkinson's Disease Model, Distinct from Cigarette Aerosols.Chemical research in toxicology · 2026Article
- Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Action potential: Impact of climate change on neurological disease in Ireland.Irish journal of medical science · 2026Review
- Mapping cellular vulnerability in Parkinson's disease using retro-AAVs and preformed α-synuclein fibrils.Translational neurodegeneration · 2026Article
- Environmental determinants of neurotoxicity: role of heavy metals in neurological disorders.Frontiers in neurology · 2026Review
- Air Pollution and Parkinson's Disease Pathology: Clinical Evidence and the Molecular Mechanisms Linking Airborne Toxicants to Neuroinflammation and Neurodegeneration.Parkinson's disease · 2026Review
- Molecular Crossroads: Shared and Divergent Molecular Signatures in Alzheimer's Disease and Dementia with Lewy Bodies.International journal of molecular sciences · 2025Review
- Hospitalized Adults' Willingness to Use Mobile Apps for Air Quality and Heat Monitoring: A Survey-Based Study.International journal of environmental research and public health · 2025Article
- Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras.bioRxiv : the preprint server for biology · 2025Article
- Regulation of autophagy by a tRNA-derived fragment.Nature reviews. Nephrology · 2025Article
- Incidental vs. Engineered Nanoparticles in Alzheimer's and Parkinson's Disease: Pathological Pathways and Therapeutic Interventions.Nano research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors.
Xiaodi Zhang *Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5452-4027
Haiqing Liu *Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5721-0728
Xiao Wu *Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID 0000-0002-4884-657X
Longgang Jia *Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3400-5531
Kundlik GadhaveNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4530-4772
Lena WangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kevin ZhangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hanyu LiNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0005-3510-4787
Rong ChenNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9291-5539
Ramhari KumbharNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8975-2502
Ning WangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-3410-8509
Chantelle E TerrillionDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0005-9266-8845
Bong Gu KangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-0594-9509
Bin BaiDepartment of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-6979-7412
Minhan ParkDepartment of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-7289-4053
Ma Cristine Faye DennaDepartment of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0009-0000-6817-6393
Shu ZhangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6816-0172
Wenqiang ZhengNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Denghui YeNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Xiaoli RongNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Liu YangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lili NiuNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Han Seok KoNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0864-5239
Weiyi PengDepartment of Biology and Biochemistry, University of Houston, Houston, TX, USA.ORCID 0000-0002-7785-6240
Lingtao JinDepartment of Molecular Medicine, the University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Mingyao YingDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6215-4959
Liana S RosenthalDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5140-3967
David W NauenDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2652-9944
Alex PantelyatDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6427-7485
Mahima KaurDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-7147-4084
Kezia IreneDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-4719-2639
Liuhua ShiVertex Pharmaceuticals Incorporated, Boston, MA, USA.
Rahel FelekeDepartment of Metabolism, Digestion and Reproduction - Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0003-2873-7525
Sonia García-RuizUK Dementia Research Institute at The University of Cambridge, Cambridge, UK.ORCID 0000-0003-4913-5312
Mina RytenUK Dementia Research Institute at The University of Cambridge, Cambridge, UK.ORCID 0000-0001-9520-6957
Valina L DawsonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2915-3970
Francesca DominiciDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-9382-0141
Rodney J WeberDepartment of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0003-0765-8035
Xuan ZhangDepartment of Life and Environmental Sciences, University of California, Merced, Merced, CA, USA.ORCID 0000-0003-1548-8021
Pengfei LiuDepartment of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0001-7280-9720
Ted M DawsonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6459-0893
Shizhong HanLieber Institute for Brain Development, Baltimore, MD, USA.ORCID 0000-0002-5114-6742
Xiaobo MaoNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6587-556X
Funding
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7MResearch Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI CONSTANTINE G LYKETSOS · 2020 to 2026
$29.3MMurine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9MNational Cohort Studies of Alzheimer's Disease, Related Dementias and Air PollutionR01AG066793 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2020 to 2025
$4.2MIntegrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health StudiesR01ES030616 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DOMINICI, FRANCESCA, KIOUMOURTZOGLOU, MARIANTHI-ANNA · 2020 to 2024
$3.1MNetwork biology-based markers of extreme weather-induced neurodegenerationP20AG093975 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERHANE, KIROS T · 2024 to 2025
$2.8MSusceptibility and adverse health outcomes related to climate-sensitive events among older Medicare beneficiaries with Alzheimer and DementiaRF1AG080948 · NIA · YALE UNIVERSITY · PI BELL, MICHELLE L, BENMARHNIA, TARIK · 2023 to 2023
$2.6MThe confluence of extreme heat cold on the health and longevity of an Aging Population with Alzheimers and related DementiaRF1AG074372 · NIA · HARVARD MEDICAL SCHOOL · PI DOMINICI, FRANCESCA, ESTIRI, HOSSEIN · 2022 to 2023
$2.6MDetermine the role of atmospheric particulate matter pollutants in contributing to Lewy Body DementiaRF1AG079487 · NIA · JOHNS HOPKINS UNIVERSITY · PI LIU, PENGFEI, MAO, XIAOBO · 2023 to 2023
$2.3Mα-Synuclein strain properties are associated with diagnosis of and progression to Parkinson's disease with dementiaR01NS125592 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Xiaobo Mao, Liana Isa Shapiro Rosenthal · 2025 to 2026
$1.3MSusceptibility and adverse health outcomes related to weather-sensitive events among older Medicare beneficiaries with Alzheimer and DementiaR01AG080948 · NIA · YALE UNIVERSITY · PI Michelle L Bell, Tarik Benmarhnia · 2026 to 2026
$725kEstablishing a unified evaluation and implementation framework to inform heat-health warning systemsK01ES036202 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WU, XIAO · 2025 to 2025
$158kNIA NIH HHS P20 AG093975NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG066793NIA NIH HHS R01 AG080948NIA NIH HHS RF1 AG074372NIA NIH HHS RF1 AG079487NIA NIH HHS RF1 AG080948NIEHS NIH HHS K01 ES036202NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES030616NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS125592
Abstract
Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. In this work, we showed in a cohort of 56.5 million individuals across the United States that fine particulate matter (PM
Indexed as
Air Pollutantsalpha-SynucleinBrainEnvironmental ExposureLewy Body DiseaseParticulate MatterAgedAir PollutionAnimalsAtrophyChinaFemaleHumansIncidenceMaleMiceAir Pollutantsalpha-SynucleinParticulate Matter
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.