ArticleScience (New York, N.Y.)2025
Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- Proteomic identification of resistin as a NET-associated neutrophil activity marker in sepsis.Journal of intensive care · 2026Article
- Immature neutrophils sound the alarm in acute myocardial infarction.Nature cardiovascular research · 2026Article
- The Immune System as a Proarrhythmic Mediator: A Novel Paradigm for the Development of New Antiarrhythmic Therapy.The Canadian journal of cardiology · 2026Review
- Resistin in Tissue Remodeling and Fibrosis: A New Frontier.Biomolecules · 2026Review
- Interstitial cells and arrhythmia.American journal of physiology. Cell physiology · 2026Review
- The role of chemokines and their receptors in cardiovascular diseases.Frontiers in immunology · 2026Review
- Neutrophil Heterogeneity after Myocardial Infarction.Journal of innate immunity · 2026Review
- Editorial: Sudden cardiac death: mechanisms, risk and prevention.Frontiers in cardiovascular medicine · 2026Article
- Context-dependent roles of resistin-like molecule β in mucosal defense and inflammatory diseases.Frontiers in immunology · 2026Review
- Resistin-like molecule-γ promotes arrhythmia and cell death after MI.Nature reviews. Cardiology · 2025Article
- Neutrophils in Myocardial Infarction.JACC. Basic to translational science · 2025Article
- Poking holes in the heart's rhythm.Science (New York, N.Y.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Nina KumowskiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3355-9102
Steffen PabelCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jana GruneCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6209-7416
Noor MominCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3145-6089
Van K NinhUniversity of California, San Diego Department of Medicine and Bioengineering, La Jolla, CA, USA.ORCID 0000-0001-6017-4035
Laura StengelDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Kyle I MentkowskiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6623-2096
Yoshiko IwamotoCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yi ZhengDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0009-0007-8426-8117
I-Hsiu LeeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7200-7867
Jessica MatthiasAbberior Instruments America, Bethesda, MD, USA.ORCID 0000-0001-6560-2174
Jan O WirthAbberior Instruments America, Bethesda, MD, USA.ORCID 0000-0002-6471-9626
Fadi E PulousCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0794-8078
Hana SeungCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0009-0004-7754-787X
Alexandre PaccaletCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6331-562X
Charlotte G MuseCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4412-0250
Kenneth K Y TingCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6851-7124
Paul DelgadoCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4554-9924
Andrew J M LewisRadcliffe Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, and British Heart Foundation Centre of Research Excellence, Oxford, UK.ORCID 0000-0002-3714-6711
Vaishali KaushalDivision of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Antonia KresoDivision of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0632-958X
Dennis BrownProgram in Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sikander HayatDepartment of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology Hypertension), RWTH Aachen, Medical Faculty, Aachen, Germany.ORCID 0000-0001-5919-8371
Rafael KramannDepartment of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology Hypertension), RWTH Aachen, Medical Faculty, Aachen, Germany.ORCID 0000-0003-4048-6351
Filip K SwirskiCardiovascular Research Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3163-9152
Kamila NaxerovaCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7744-5110
Daniel C PropheterDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8665-0885
Lora V HooperDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2759-4641
Michael A MoskowitzCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kevin R KingUniversity of California, San Diego Department of Medicine and Bioengineering, La Jolla, CA, USA.ORCID 0000-0003-1472-2189
Nadia RosenthalThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-7599-7365
Maarten HulsmansCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1009-658X
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4021-1887
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Deborah J Wexler · 2023 to 2026
$5.4MCardiac resident macrophages in AV node conductionR01HL149647 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2022 to 2025
$2.9MMacrophage heterogeneity in atrial remodelingR01HL155097 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2021 to 2025
$2.9MMacrophages in Cardiovascular HealthR35HL176359 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2025 to 2026
$2.2MThe Skull Bone Marrow Niche After StrokeR37NS136068 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Michael A. Moskowitz, Matthias Nahrendorf · 2025 to 2026
$1.6MBiological Mechanisms of the Infarct BorderzoneR01HL181539 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin R King · 2025 to 2026
$1.5MHD Upgrade to a Nikon A1R Confocal Imaging PlatformS10OD032211 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2022 to 2022
$296kNHLBI NIH HHS P01 HL142494NHLBI NIH HHS R01 HL149647NHLBI NIH HHS R01 HL155097NHLBI NIH HHS R01 HL181539NHLBI NIH HHS R35 HL176359NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK135043NIH HHS S10 OD032211NINDS NIH HHS R37 NS136068
Abstract
Ventricular tachycardia disrupts the heart's coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrhythmias. Comparing neutrophils with macrophages, we found that resistin-like molecule γ (
Indexed as
Cell MembraneMyocytes, CardiacResistinTachycardia, VentricularAnimalsHumansImmunity, InnateMacrophagesMiceMice, Inbred C57BLMyocardial InfarctionNeutrophilsResistinRETN protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.