ArticleScience (New York, N.Y.)2025
Evolution of thumbnails across Rodentia.
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Multi-area activity in mouse motor cortex associated with one- and two-handed oromanual dexterity.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The unguis (hoof, claw, or nail) of the first digit (D1, also known as the thumb or pollex) of the tetrapod hand exhibits numerous functional adaptations, but its macroevolutionary association with ecological diversity is unknown. Across Rodentia, we find that most extant genera and ancestral lineages bear D1 nails. Exceptions follow structure-function associations that arose independently multiple times, specifically, the gain of D1 claws with subterranean habits and the loss of D1 ungues with oral-only feeding behavior. We hypothesize that early acquisition of D1 nails and manually dexterous food handling was crucial for rodents to adaptively leverage cranial specializations for efficient gnawing and thereby exploit hard seeds and nuts, a niche that they dominated after the extinction of multituberculates. Our study recasts ideas about rodent evolution and uncovers a previously unrecognized contributor to their successful radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.