Evidence map›Paper›PMID 40906828›Full record

ArticleJournal of chemical information and modeling2025

A Machine Learning Model for the Proteome-Wide Prediction of Lipid-Interacting Proteins.

Jonathan Chiu-Chun Chou, Poulami Chatterjee, Cassandra M Decosto, Laura M K Dassama

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. TheVirulence · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jonathan Chiu-Chun ChouDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Poulami ChatterjeeDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Cassandra M DecostoDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Laura M K DassamaDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-0851-6373

Funding

Deciphering the molecular mechanisms of sterol lipid trafficking in bacteriaR35GM150910 · NIGMS · STANFORD UNIVERSITY · PI Laura Dassama · 2023 to 2026
$1.9M
NIGMS NIH HHS R35 GM150910
6 · The paper itself

Abstract

Lipids are essential metabolites that play critical roles in multiple cellular pathways. Like many primary metabolites, mutations that disrupt lipid synthesis can be lethal. Proteins involved in lipid synthesis, trafficking, and modification, are targets for therapeutic intervention in infectious disease and metabolic disorders. The ability to rapidly detect these proteins can accelerate their evaluation as targets for deranged lipid pathologies. However, it remains challenging to identify lipid binding motifs in proteins because the rules that govern protein engagement with specific lipids are poorly understood. As such, new bioinformatic tools that reveal conserved features in lipid binding proteins are necessary. Here, we present

Indexed as

LipidsMachine LearningProteinsProteomeAlgorithmsBinding SitesComputational BiologyHumansHydrophobic and Hydrophilic InteractionsModels, MolecularProtein BindingLipidsProteinsProteome

Identifiers

PMID40906828
PMCPMC12458687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.