Evidence map›Paper›PMID 40906813›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Testis expressed 50 is essential for maintaining sperm acrosome integrity during epididymal transit.

Saori Haga, Kaori Nozawa, Ferheen Abbasi, Katarzyna Kent, Naoko Nagasawa, Tsutomu Endo, Haruhiko Miyata, Masahito Ikawa, Martin M Matzuk, Yoshitaka Fujihara

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saori HagaDepartment of Advanced Medical Technologies, National Cerebral and Cardiovascular Center, Suita, Osaka 564-8565, Japan.
Kaori NozawaDepartment of Advanced Medical Technologies, National Cerebral and Cardiovascular Center, Suita, Osaka 564-8565, Japan.
Ferheen AbbasiResearch Institute for Microbial Diseases, Department of Experimental Genome Research, The University of Osaka, Suita, Osaka 565-0871, Japan.
Katarzyna KentCenter for Drug Discovery, Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-4528-3425
Naoko NagasawaDepartment of Advanced Medical Technologies, National Cerebral and Cardiovascular Center, Suita, Osaka 564-8565, Japan.
Tsutomu EndoGraduate School of Agricultural and Life Sciences, Department of Animal Resource Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.ORCID 0000-0001-9394-362X
Haruhiko MiyataResearch Institute for Microbial Diseases, Department of Experimental Genome Research, The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-4758-5803
Masahito IkawaResearch Institute for Microbial Diseases, Department of Experimental Genome Research, The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0000-0001-9859-6217
Martin M MatzukCenter for Drug Discovery, Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-1445-8632
Yoshitaka FujiharaDepartment of Advanced Medical Technologies, National Cerebral and Cardiovascular Center, Suita, Osaka 564-8565, Japan.ORCID 0000-0001-8332-3507

Funding

Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
Comprehensive Mechanisms in Reproductive SciencesT32HD098068 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI STEPHANIE A. PANGAS · 2020 to 2026
$2.4M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD088412HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) T32GM139534-01HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) T32HD098068Japan Agency for Medical Research and Development (AMED) JP18gm5010001MEXT | Japan Society for the Promotion of Science (JSPS) JP19H05750MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05033MEXT | Japan Society for the Promotion of Science (JSPS) JP21K19198Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP20KK0155Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP21H02397Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP24H00545
6 · The paper itself

Abstract

In mammals, sperm formation is completed in the seminiferous tubules within the testis, and sperm maturation occurs during the epididymal transit of the spermatozoa. Sperm morphology drastically changes when abnormal spermatozoa migrate from the testis to the epididymis. Detailed molecular mechanisms for sperm survival in the epididymis have not been determined yet. Globozoospermia is a cause of male infertility and is characterized by round-headed spermatozoa without acrosomes, an abnormal sperm nuclear membrane, and sperm midpiece defects.

Indexed as

AcrosomeEpididymisMembrane ProteinsSpermatozoaTestisAcrosome ReactionAnimalsInfertility, MaleMaleMiceMice, KnockoutSpermatogenesisSperm MotilityMembrane ProteinsacrosomeCRISPR-Cas9epididymisinfertilityspermatogenesis

Identifiers

PMID40906813
PMCPMC12435281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.