Evidence map›Paper›PMID 40906340›Full record

ArticleDigestive diseases and sciences2025

Adult Patients with Celiac Disease Are Under-Vaccinated Against Pneumococcal Disease: A Quality Improvement Study.

Kaitlin Payne, Claire Jansson-Knodell, Emily Trommer, Andrew Ford, Kendra Weekley, David Gardinier, Alberto Rubio-Tapia

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. From Villi to Alveoli: Lung Involvement in Celiac Disease - A Narrative Review.Journal of community hospital internal medicine perspectives · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaitlin PayneDivision of Gastroenterology and Hepatology, Department of Medicine, Tufts Medical Center, Boston, MA, USA. kaitlin.payne@gmail.com.
Claire Jansson-KnodellCeliac Disease Program, Gastroenterology, Hepatology, and Nutrition, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
Emily TrommerCeliac Disease Program, Gastroenterology, Hepatology, and Nutrition, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
Andrew FordDivision of Gastroenterology and Hepatology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH, USA.
Kendra WeekleyCeliac Disease Program, Gastroenterology, Hepatology, and Nutrition, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
David GardinierCeliac Disease Program, Gastroenterology, Hepatology, and Nutrition, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
Alberto Rubio-TapiaCeliac Disease Program, Gastroenterology, Hepatology, and Nutrition, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with celiac disease (CeD) are at increased risk of pneumococcal infections, and guidelines recommend vaccination against pneumococcal disease as a safe and effective strategy at reducing the risk of infection. The rate of vaccination amongst patients with CeD is unknown. The aim of this study was to evaluate current underlying vaccination rates and to improve vaccination rates through a quality improvement initiative.

methodsData regarding rates of pneumococcal vaccination amongst patients with biopsy-confirmed CeD were retrospectively collected. A prospective quality improvement initiative was then performed. An educational handout was provided to patients seen during in-person clinic visits, and the pneumococcal conjugate 20 vaccine (PCV20) was offered.

resultsA total of 340 patients were initially reviewed. Only 78 patients (21%) were adequately vaccinated against pneumococcal infection. In the prospective portion, 93 CeD patients were seen in the office during the period of intervention, 33 of whom were already vaccinated (35%). The handout was given to 42/60 eligible patients, the majority of whom were vaccinated during the same clinic visit (62%). Of patients who did not receive the flier, 2/18 were vaccinated in the office. Patients were significantly more likely to get vaccinated after receiving the handout (odds ratio (OR) 13.0; 95% CI 2.6-64.2; p = 0.0016). DISCUSSION: Patients with CeD are under-vaccinated against pneumococcal disease. Providing educational resources and administering PCV20 during in-person GI office visits appears to be an effective strategy to increase vaccination rates.

Indexed as

Celiac DiseasePneumococcal InfectionsPneumococcal VaccinesQuality ImprovementVaccinationAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesRetrospective StudiesPneumococcal VaccinesCeliac diseasePneumococcal diseasePneumococcal vaccinationQuality improvement

Identifiers

PMID40906340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.