ArticlePediatric radiology2025
Does the addition of fentanyl premedication impact brown fat uptake in children undergoing a warming protocol for FDG PET?
Article in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
backgroundFentanyl is used in some pediatric practices with a goal of suppressing 18F-fluorodeoxyglucose (18F-FDG) uptake in brown fat.
objectiveThe purpose of this study was to examine the frequency, intensity, and distribution of brown fat uptake in warmed children undergoing 18F-FDG PET/CT with and without premedication with fentanyl. MATERIALS AND
methodsThis retrospective study included children (< 18 years old) who underwent 18F-FDG-PET from 2014 to 2024 at a center that routinely warms patients and uses intravenous fentanyl for brown fat suppression for most patients. Three radiologists assessed the presence, intensity, and location of brown fat uptake. Chi-square test and two-sample t-test were used to compare the demographics and brown fat uptake between premedication and non-premedication groups.
resultsAmong 873 18F-FDG-PETs, 595 (68%) were performed with fentanyl premedication and warming and 278 (32%) were conducted with warming alone. Brown fat uptake was observed in 46 (5.3%) FDG-PETs, 32/595 (5.4%) in the premedicated group and 14/278 (5.0%) in the non-premedicated group (P = 0.83). No differences were found in brown fat intensity or location based on premedication status. Age (14.5 vs. 8.5; P < 0.001) and BMI (20.1 vs. 17.7; P < 0.001) were significantly associated with brown fat uptake.
conclusionFentanyl premedication does not significantly affect brown fat uptake frequency, intensity, or location in warmed children undergoing 18F-FDG-PET.
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