Evidence map›Paper›PMID 40906189›Full record

ReviewZeitschrift fur Rheumatologie2025

[Chimeric antigen receptor T-cells for patients with hematologic malignancies].

Maria-Luisa Schubert, Peter Dreger, Michael Schmitt

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Zeitschrift fur Rheumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria-Luisa SchubertMedizinische Klinik V (Hämatologie, Onkologie und Rheumatologie), Deutsches Konsortium für Tumorerkrankungen (DKTK) und Nationales Zentrum für Tumorerkrankungen (NCT), Universitätsklinikum Heidelberg (UKHD), Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland.
Peter DregerMedizinische Klinik V (Hämatologie, Onkologie und Rheumatologie), Deutsches Konsortium für Tumorerkrankungen (DKTK) und Nationales Zentrum für Tumorerkrankungen (NCT), Universitätsklinikum Heidelberg (UKHD), Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland.
Michael SchmittMedizinische Klinik V (Hämatologie, Onkologie und Rheumatologie), Deutsches Konsortium für Tumorerkrankungen (DKTK) und Nationales Zentrum für Tumorerkrankungen (NCT), Universitätsklinikum Heidelberg (UKHD), Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland. michael.schmitt@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The targeted and personalized cell and gene therapy with autologous chimeric antigen receptor (CAR) transduced T‑cells (CAR T‑cells) has become established as the standard therapy for patients with B‑cell diseases, such as CD-19 positive leukemia and lymphomas and B‑cell maturation antigen (BCMA) positive multiple myeloma (MM). This therapy has been approved in Europe since 2018 and is administered in more than 50 clinics in Germany. With increasing experience and expertise in understanding of the principles of action and underlying mechanisms as well as mitigation of side effects have significantly improved. In the near future expansion of CAR T‑cell applications are to be expected, aimed at addressing further targets and therefore other disease entities. Currently, the indications have already expanded beyond hematology and oncology to rheumatology, neurology and other fields.

Indexed as

Hematologic NeoplasmsImmunotherapy, AdoptiveReceptors, Chimeric AntigenT-LymphocytesEvidence-Based MedicineGermanyHumansTreatment OutcomeReceptors, Chimeric AntigenB‑cell diseasesCAR T‑cellsCell and gene therapyIndicationsPrinciple of action

Identifiers

PMID40906189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.