Evidence map›Paper›PMID 40906146›Full record

ArticleBiology2025

Oral Ingestion of Bean Sprouts Containing the HASPIN Inhibitor Coumestrol Increased Blood Testosterone Levels in Men.

Keisuke Kakazu, Akira Tsujimura, Yasushi Miyagawa, Kentaro Takezawa, Kazuhiro Kobayashi, Ryoji Yoshimura, Kensuke Nakajima, Seitaro Kamiya, Hiromitsu Tanaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keisuke KakazuLaboratory of Molecular Biology, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo 859-3298, Nagasaki, Japan.ORCID 0009-0005-8910-4168
Akira TsujimuraDepartment of Urology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu 279-0021, Chiba, Japan.ORCID 0000-0002-3821-5184
Yasushi MiyagawaDepartment of Urology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan.
Kentaro TakezawaDepartment of Urology, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan.ORCID 0000-0003-1137-1846
Kazuhiro KobayashiD Clinic Tokyo, 1-11-1, Chiyoda 100-6210, Tokyo, Japan.
Ryoji YoshimuraDepartment of Health and Nutrition, Faculty of Health Management, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo 859-3298, Nagasaki, Japan.
Kensuke NakajimaDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo 859-3298, Nagasaki, Japan.
Seitaro KamiyaDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo 859-3298, Nagasaki, Japan.
Hiromitsu TanakaLaboratory of Molecular Biology, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo 859-3298, Nagasaki, Japan.ORCID 0000-0002-0170-5323

Funding

Japan Society for the Promotion of Science KAKENHI 24K12454
6 · The paper itself

Abstract

Extending healthy lifespans is an important public health goal in societies with a long life expectancy. Late-onset hypogonadism (LOH), a condition associated with an age-related decrease in testosterone level, contributes to the onset of various diseases. Previously, we demonstrated that the oral ingestion of bean sprouts rich in the HASPIN inhibitor coumestrol increased blood testosterone levels in mice. In the present study, we showed that the oral ingestion of bean sprouts also led to increased blood testosterone levels in humans. These results suggested that bean sprouts, which are rich in coumestrol, have potential as a dietary intervention for the treatment of LOH.

Indexed as

health promotionisoflavonelate-onset hypogonadismlongevitynutritionpolyphenol

Identifiers

PMID40906146
PMCPMC12383465

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.