Evidence map›Paper›PMID 40906124›Full record

ArticleActa crystallographica. Section F, Structural biology communications2025

Improved structure of mouse gasdermin D: a new blueprint for structure-based drug design.

Luigi De Colibus, Patryk Ludzia, Antonio Biasutto, Andrea Pica, Jonathan T S Hopper, Ali Jazayeri, Katharina L Dürr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luigi De ColibusOMass Therapeutics, Building 4000, Chancellor Court, John Smith Drive, Oxford Business Park, ARC, Oxford OX4 2GX, United Kingdom.
Patryk LudziaDepartment of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.
Antonio BiasuttoOMass Therapeutics, Building 4000, Chancellor Court, John Smith Drive, Oxford Business Park, ARC, Oxford OX4 2GX, United Kingdom.
Andrea PicaALPX, 71 Avenue des Martyrs, 38000 Grenoble, France.ORCID 0000-0002-8736-8742
Jonathan T S HopperOMass Therapeutics, Building 4000, Chancellor Court, John Smith Drive, Oxford Business Park, ARC, Oxford OX4 2GX, United Kingdom.
Ali JazayeriOMass Therapeutics, Building 4000, Chancellor Court, John Smith Drive, Oxford Business Park, ARC, Oxford OX4 2GX, United Kingdom.
Katharina L DürrOMass Therapeutics, Building 4000, Chancellor Court, John Smith Drive, Oxford Business Park, ARC, Oxford OX4 2GX, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gasdermin D (GSDMD) is a protein that has gained significant attention in recent years due to its crucial role in inflammatory cell death, particularly pyroptosis. Pyroptosis is a highly inflammatory form of programmed cell death that is triggered by various microbial infections and sterile inflammatory stimuli. GSDMD acts as an executioner molecule in this process, leading to the release of pro-inflammatory cytokines and amplifying the immune response. Here, we present a higher resolution, significantly improved apo crystal structure of the deposited mouse structure model that will be beneficial for structure-based drug-design approaches towards this important pharmacological target.

Indexed as

Drug DesignIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsAmino Acid SequenceAnimalsCrystallography, X-RayGasderminsGene ExpressionMiceModels, MolecularProtein ConformationPyroptosisGasderminsGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsAlphaFold3gasdermin Dinflammationpyroptosis

Identifiers

PMID40906124
PMCPMC12485496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.