Evidence map›Paper›PMID 40906112›Full record

ArticleBiology2025

Explainable AI for Oral Cancer Diagnosis: Multiclass Classification of Histopathology Images and Grad-CAM Visualization.

Jelena Štifanić, Daniel Štifanić, Nikola Anđelić, Zlatan Car

Abstract read
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jelena ŠtifanićFaculty of Engineering, University of Rijeka, Vukovarska 58, 51000 Rijeka, Croatia.ORCID 0000-0002-5213-1550
Daniel ŠtifanićFaculty of Engineering, University of Rijeka, Vukovarska 58, 51000 Rijeka, Croatia.ORCID 0000-0001-9396-2441
Nikola AnđelićFaculty of Engineering, University of Rijeka, Vukovarska 58, 51000 Rijeka, Croatia.ORCID 0000-0002-0314-243X
Zlatan CarFaculty of Engineering, Catholic University of Croatia, Ilica 244, 10000 Zagreb, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cancer is typically diagnosed through histological examination; however, the primary issue with this type of procedure is tumor heterogeneity, where a subjective aspect of the examination may have a direct effect on the treatment plan for a patient. To reduce inter- and intra-observer variability, artificial intelligence algorithms are often used as computational aids in tumor classification and diagnosis. This research proposes a two-step approach for automatic multiclass grading using oral histopathology images (the first step) and Grad-CAM visualization (the second step) to assist clinicians in diagnosing oral squamous cell carcinoma. The Xception architecture achieved the highest classification values of 0.929 (±σ = 0.087) AUC

Indexed as

artificial intelligenceexplainable deep learningGRAD-Camhistopathology imagesoral squamous cell carcinoma

Identifiers

PMID40906112
PMCPMC12383596

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.