Evidence map›Paper›PMID 40906049›Full record

ReviewMolecular diagnosis & therapy2025

Gastric Cancer Treatment New Chapter: Organoid Models Leading Personalized Medicine.

Yuan Meng, LiLi Zhang, Jie Yang, Xuerui Wang, Meiying Zhu, Fanming Kong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular diagnosis & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuan Meng *Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Changling Road No. 88, Xiqing District, Tianjin, 300381, China.
LiLi Zhang *Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Changling Road No. 88, Xiqing District, Tianjin, 300381, China.
Jie YangDepartment of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Changling Road No. 88, Xiqing District, Tianjin, 300381, China.
Xuerui WangDepartment of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Changling Road No. 88, Xiqing District, Tianjin, 300381, China.
Meiying ZhuDepartment of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Changling Road No. 88, Xiqing District, Tianjin, 300381, China.
Fanming KongDepartment of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Changling Road No. 88, Xiqing District, Tianjin, 300381, China. kongfanming08@163.com.ORCID 0009-0004-6116-6482

Funding

Hebei Provincial Administration of Traditional Chinese Medicine Research Project T2025083
6 · The paper itself

Abstract

Gastric cancer is a highly heterogeneous disease, with substantial variations observed among patients in clinical manifestation, histological characteristics, and drug sensitivities. Achieving precision medicine necessitates a comprehensive understanding of the molecular mechanisms underlying gastric cancer and the establishment of robust preclinical models. Organoids, cultivated from cancer cells within tumor tissues, utilizing three-dimensional tissue culture techniques, faithfully replicate the features and heterogeneity of in vivo tumors and have emerged as a promising platform. This review explores the application of gastric cancer-derived organoids (GCOs) in preclinical research and clinical translation, highlighting current challenges and outlining future prospects. Although this technology remains some distance from direct clinical application, it holds tremendous potential for clinical utilization.

Indexed as

OrganoidsPrecision MedicineStomach NeoplasmsAnimalsAntineoplastic AgentsHumansAntineoplastic Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.