Trial reportEuropean journal of pediatrics2025
Assessment of the role of probiotics in prevention of ventilator-associated pneumonia in neonates.
Trial report in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07001163 (Assessment of the Role of Probiotics in Prevention of Ventilator-Associated Pneumonia in Neonates), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Assessment of the Role of Probiotics in Prevention of Ventilator-Associated Pneumonia in Neonates
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVentilator-associated pneumonia (VAP) is a severe complication in NICUs. It increases morbidity, mortality, and healthcare costs. The research purpose was to evaluate the preventive value of probiotics on the incidence of VAP among ventilated neonates.
methodsThis prospective randomized controlled study was done at the NICU of Tanta University Hospitals for one year. Eighty full-term neonates who required invasive mechanical ventilation for over 48 h were randomly divided into a probiotic group (n = 40) and a non-probiotic group (n = 40). Besides the standard treatment that was given to both groups, the probiotic group received a sachet containing 1 × 10
resultsThe incidence of VAP was significantly lower in the probiotics group (20%) compared to the non-probiotic group (47.5%) with an OR of 0.28 (95% CI: 0.10-0.75). Additionally, administration of probiotics was associated with a significantly lower incidence of feeding intolerance, vomiting, and abdominal distension (17.5%, 12.5%, and 10.0% vs. 44.0%, 40.0%, and 44.0% in probiotic and non-probiotic groups, respectively) with OR = 0.26, 0.21, and 0.18, respectively. On the other hand, there was a significantly shorter duration of mechanical ventilation in the probiotic group over the non-probiotic group (MD = 10 days, 95% CI: 6.30-13.70). Similarly, NICU stay was significantly shorter in the probiotic group compared to the non-probiotic group (MD = 8 days, 95% CI: 3.29-12.71). Conclusion Probiotics seem to be effective in the prevention of VAP among mechanically ventilated neonates. CLINICAL
trial registrationClinicaltrials.gov/ NCT07001163; registered May 23, 2025. WHAT IS KNOWN: • VAP is a common and serious nosocomial infection in mechanically ventilated neonates, associated with prolonged hospitalization and increased mortality • Current VAP preventive strategies focus on infection control and supportive care measures • In neonatal care, probiotics have shown efficacy in reducing necrotizing enterocolitis (NEC) and late-onset sepsis incidence in preterms What is new: • Probiotics have shown potential in enhancing mucosal barrier function, competing with pathogenic bacteria, and supporting systemic immune responses. Therefore, probiotic supplementation could have clinical efficacy in the prevention of VAP in NICUs.
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