Evidence map›Paper›PMID 40906013›Full record

ArticleSports medicine (Auckland, N.Z.)2026

Neurodegenerative Diseases in Male Former First-Class New Zealand Rugby Players.

Francesca Anns, Kenneth L Quarrie, Barry J Milne, Chao Li, Andrew J Gardner, Ian R Murphy, Evert Verhagen, Craig Wright, Susan M B Morton, Thomas Lumley and 2 more

Abstract read
In one paragraph

Article in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca AnnsCentre of Methods and Policy Application in the Social Sciences, Faculty of Arts and Education, University of Auckland, Auckland, New Zealand.ORCID 0009-0006-7276-0211
Kenneth L QuarrieNew Zealand Rugby, Wellington, New Zealand.ORCID 0000-0003-1703-8489
Barry J MilneCentre of Methods and Policy Application in the Social Sciences, Faculty of Arts and Education, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-0318-1201
Chao LiCentre of Methods and Policy Application in the Social Sciences, Faculty of Arts and Education, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-4316-5548
Andrew J GardnerSydney School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0001-5031-5586
Ian R MurphyIllawarra-Shoalhaven Local Health District, New South Wales Health, Warrawong, NSW, Australia.ORCID 0009-0009-3922-9869
Evert VerhagenAmsterdam Collaboration on Health and Safety in Sports, Department of Public and Occupational Health, Amsterdam Movement Sciences, Amsterdam UMC, Amsterdam, The Netherlands.ORCID 0000-0001-9227-8234
Craig WrightSocial Investment Agency, Wellington, New Zealand.ORCID 0009-0000-3512-9099
Susan M B MortonResearch Institute for Innovative Solutions for Well-being and Health, Faculty of Health, University of Technology, Sydney, Australia.ORCID 0000-0002-2231-7020
Thomas LumleyDepartment of Statistics, Faculty of Science, University of Auckland, Auckland, New Zealand.ORCID 0000-0003-4255-5437
Lynette TippettSchool of Psychology, Faculty of Science, University of Auckland, Auckland, New Zealand.ORCID 0000-0003-4592-6600
Stephanie D'SouzaCentre of Methods and Policy Application in the Social Sciences, Faculty of Arts and Education, University of Auckland, Auckland, New Zealand. s.dsouza@auckland.ac.nz.ORCID 0000-0003-1458-2147

Funding

New Zealand Rugby Foundation G-2004-00963
6 · The paper itself

Abstract

backgroundGrowing concern surrounds the risk of neurodegenerative diseases in high-level collision sports, but research on Rugby Union's connection to these diseases is limited.

objectiveThis study sought to examine the long-term neurodegenerative disease risk associated with participation in high-level Rugby Union ('rugby'), utilising whole-population administrative records.

methodsThis retrospective cohort study in New Zealand compared males born between 1920 and 1984 who were active in high-level (provincial or higher) rugby between 1950 and 2000 (n = 12,861) with males from the general population (n = 2,394,300), matched by age, ethnicity, and birthplace. We used Cox proportional hazards models to assess risks of Alzheimer's disease, Parkinson's disease, motor neuron disease, and other dementias, ascertained using mortality and hospitalisation records from January 1988 to June 2023.

resultsA higher percentage of rugby players (6.5%) than males in the general population (5.2%) developed neurodegenerative diseases, with hazard ratios indicating players showed increased risks for any neurodegenerative disease (1.22; 95% confidence interval [CI] 1.14-1.30), Alzheimer's disease (1.61; 95% CI 1.42-1.83), and other dementias (1.23; 95% CI 1.14-1.33). Significant differences were not observed for Parkinson's disease (1.05; 95% CI 0.89-1.22) and motor neuron disease (1.16; 95% CI 0.83-1.63). In general, this increased risk among players compared to the general population began around the ages of 70-79 years. Compared to the general population, small to moderate increased risks of any neurodegenerative disease were observed for a backline playing position, provincial and/or amateur players, international and/or professional players, participation in ≥ 2 years of play, and participation in five or more matches.

conclusionsHigh-level rugby participation amongst males in New Zealand is associated with a small to moderate increase in neurodegenerative disease rates compared to the general population.

Indexed as

FootballNeurodegenerative DiseasesAdultAgedAlzheimer DiseaseHumansMaleMiddle AgedNew ZealandParkinson DiseaseProportional Hazards ModelsRetrospective StudiesRisk Factors

Identifiers

PMID40906013
PMCPMC12982275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.