Evidence map›Paper›PMID 40905992›Full record

ArticleJournal of thrombosis and thrombolysis2026

Physical activity before venous thromboembolism and risk of recurrence in a population-based inception cohort.

Anna C Frauenheim, Kerri L Wiggins, Rozenn N Lemaitre, Nicholas L Smith, Laura B Harrington

Abstract read
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In one paragraph

Article in Journal of thrombosis and thrombolysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna C FrauenheimDepartment of Epidemiology, University of Washington, 1410 NE Campus Pkwy, Seattle, WA, 98195, USA. afrauen@uw.edu.
Kerri L WigginsDepartment of Medicine, University of Washington, Seattle, WA, USA.
Rozenn N LemaitreDepartment of Medicine, University of Washington, Seattle, WA, USA.
Nicholas L SmithDepartment of Epidemiology, University of Washington, 1410 NE Campus Pkwy, Seattle, WA, 98195, USA.
Laura B HarringtonDepartment of Epidemiology, University of Washington, 1410 NE Campus Pkwy, Seattle, WA, 98195, USA.

Funding

Genome-wide case-only study of antihypertensive drug-gene interactionsR01HL085251 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2010
$7.2M
Estrogens and pharmacogenetic risks of venous thrombosis in postmenopausal womenR01HL073410 · NHLBI · UNIVERSITY OF WASHINGTON · PI SMITH, NICHOLAS L · 2004 to 2012
$4.8M
Atrial Fibrillation: Incidence, Risk Factors, and GeneticsR01HL068986 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2002 to 2010
$3.5M
Venous Thromboembolism Sequelae in a Population-based Inception CohortR01HL166292 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI Laura Brienne Harrington · 2023 to 2026
$3.3M
CALCIUM-CHANNEL BLOCKERS AND PRIMARY PREVENTION OF CHDR01HL043201 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1991 to 2004
$3.0M
Pharmacologic and pharmacogenetic associations with recurrent venous thrombosisR01HL095080 · NHLBI · UNIVERSITY OF WASHINGTON · PI SMITH, NICHOLAS L · 2008 to 2012
$2.9M
Pharmacogenetics and Cardiovascular EventsR01HL074745 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2003 to 2006
$2.8M
Physical Activity, Sedentary Behavior, and Venous Thromboembolism RiskK01HL139997 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HARRINGTON, LAURA BRIENNE · 2018 to 2022
$942k
The Association of Vasomotor Symptoms with Thrombosis in Postmenopausal WomenR21HL121414 · NHLBI · UNIVERSITY OF WASHINGTON · PI SMITH, NICHOLAS L · 2014 to 2015
$184k
NHLBI NIH HHS HL73410NHLBI NIH HHS K01 HL139997NHLBI NIH HHS K01HL139997NHLBI NIH HHS R01 HL043201NHLBI NIH HHS R01 HL068986NHLBI NIH HHS R01 HL073410NHLBI NIH HHS R01 HL074745NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL095080NHLBI NIH HHS R01 HL166292NHLBI NIH HHS R21 HL121414
6 · The paper itself

Abstract

introductionThe association between moderate-to-vigorous physical activity (MVPA) and recurrent venous thromboembolism (VTE) is unclear, but an improved understanding could inform behavioral health recommendations.

methodsThe Heart and Vascular Health study, set in a large integrated healthcare system, identified adults with a validated incident VTE between January 2002 and December 2010. An inception cohort was formed from these cases and followed for a first recurrent VTE through December 2014. Usual MVPA pre-incident VTE was self-reported by 1381 adults via telephone interview, and MVPA amount was calculated in metabolic equivalent of task (MET) hours (h) per week. Multivariable-adjusted Cox proportional hazards models estimated adjusted hazard ratios (HR

resultsDuring follow-up (median = 5.23 years), 288 (20.9%) individuals developed a recurrent VTE. There was no evidence of an association between any MVPA versus none and VTE recurrence (HR

conclusionsIn this cohort of adults who experienced incident VTE, there was no evidence of an association between self-reported MVPA pre-incident VTE and VTE recurrence risk.

Indexed as

ExerciseVenous ThromboembolismAdultAgedCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedRecurrenceRisk FactorsExerciseHealth behaviorPhysical activityRecurrenceVenous thromboembolism

Identifiers

PMID40905992
PMCPMC12805904

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.