Diagnostic values of TPT1 in patients with sepsis, septic shock and in non-infected controls: A single-center prospective observational cohort study in ICU patients.

Gelan Miao, Dexiu Chen, Xuelian Yang, Yulian Yang, Qidong Jiang, Li Liu, Xianying Lei

Abstract readObservational Study

In one paragraph

Observational study in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gelan MiaoDepartment of Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Dexiu ChenDepartment of Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Xuelian YangDepartment of Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Yulian YangDepartment of Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Qidong JiangDepartment of Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Li LiuDepartment of Anesthesiology, The First Affiliated Hospital of Southwest Medical University, Luzhou, China.

Xianying LeiDepartment of Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID 0000-0003-4724-9324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo evaluate the diagnostic value of tumor protein translationally-controlled 1 (TPT1) in patients with sepsis and septic shock in the intensive care unit (ICU).MethodsThis single-center, prospectively planned observational study included 53 ICU patients with sepsis (30 with non-shock sepsis, 23 with septic shock) and 20 non-infected ICU controls. Plasma levels of TPT1, procalcitonin (PCT), and C-reactive protein (CRP) were measured on day 1 of ICU admission. Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis.ResultsTPT1 levels were associated with higher SOFA scores and serum creatinine levels (

Indexed as

SepsisShock, SepticAdultAgedBiomarkersC-Reactive ProteinFemaleHumansIntensive Care UnitsMaleMiddle AgedProcalcitoninProspective StudiesROC CurveTumor Protein, Translationally-Controlled 1BiomarkersC-Reactive ProteinProcalcitoninTumor Protein, Translationally-Controlled 1biomarkersICUSepsisseptic shockTPT1

Identifiers

PMID40905776

DOI10.1177/00368504251363429

PMCPMC12411722

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.