Evidence map›Paper›PMID 40905696›Full record

ArticlemSystems2025

Migration and standing variation in vaginal and rectal yeast populations in recurrent vulvovaginal candidiasis.

Abdul-Rahman Adamu Bukari, Rebekah J Kukurudz-Gorowski, Alexia de Graaf, Devin A Habon, Beamlak Manyaz, Yana Syvolos, Aruni Sumanarathne, Vanessa Poliquin, Aleeza C Gerstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Phenotypic and genotypic analysis ofInfection and immunity · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdul-Rahman Adamu BukariDepartment of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0002-0923-3893
Rebekah J Kukurudz-GorowskiDepartment of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.
Alexia de Graaf *Department of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.
Devin A Habon *Department of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.
Beamlak Manyaz *Department of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.
Yana SyvolosDepartment of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.
Aruni SumanarathneDepartment of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.
Vanessa PoliquinObstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Aleeza C GersteinDepartment of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0002-0781-9356

Funding

Canadian Institute for Advanced Research Azrieli Global ScholarManitoba Medical Service Foundation Research Operating GrantNatural Sciences and Engineering Research Council of Canada Discovery Grant,CREATE Training GrantResearch Manitoba New Investigator Operating Grant - Basic BiomedicalUniversity of Manitoba Faculty of Science Collaboration Grant,URA,UofM Science Students Association and FoS USRA,FoS USRA
6 · The paper itself

Abstract

Vulvovaginal candidiasis is a very common human fungal infection. Most are successfully treated with antifungal drugs, yet ~8% lead to recurrent vulvovaginal candidiasis (RVVC). Vaginal and rectal populations have been previously found to be closely related in RVVC. Yet the genomic methods used precluded the assessment of fine-scale relationships and the measurement of within-population variation, a fundamental property with evolutionary implications. To address this gap, we isolated 12 vaginal and 12 rectal yeast isolates from four individuals with a history of RVVC. Three individuals had IMPORTANCE: Vaginal yeast infections are very common, yet we do not understand why some people experience chronic infections when most have a single infection that is successfully treated and cleared. We examined 12 vaginal and 12 rectal yeast isolates from four individuals with a history of recurrent yeast infections (total 96 isolates). Three participants had a

Indexed as

Candidiasis, VulvovaginalRectumVaginaAdultAntifungal AgentsCandida albicansFemaleGenetic VariationHumansPhylogenyRecurrenceWhole Genome SequencingAntifungal AgentsCandida albicansNakaseomyces glabratusrecurrent vulvovaginal candidiasisyeast genomicsyeast infection

Identifiers

PMID40905696
PMCPMC12455997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.