Evidence map›Paper›PMID 40905579›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Design, synthesis, and evaluation of novel pinane-based thiazolidione derivatives with anti-glioblastoma activity.

Wei Shi, Min Hu, Jiale Han, Lei Wang, Yining Jiang, Hongmei Wu, Wei Liu, Biao Xiong, Yunyun Wang

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei ShiState Key Laboratory of Natural Medicines, Departemnt of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Min HuSchool of Pharmacy, Nantong University, Nantong, China.
Jiale HanSchool of Pharmacy, Nantong University, Nantong, China.
Lei WangSchool of Pharmacy, Nantong University, Nantong, China.
Yining JiangDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, China.
Hongmei WuSchool of Pharmacy, Nantong University, Nantong, China.
Wei LiuSchool of Pharmacy, Nantong University, Nantong, China.
Biao XiongSchool of Pharmacy, Nantong University, Nantong, China.
Yunyun WangSchool of Pharmacy, Nantong University, Nantong, China.ORCID 0000-0002-0102-9898

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of pinane-based thiazolidione derivatives were synthesised, and their anti-proliferative effects were investigated by CCK-8 assay. All these compounds exhibited anti-proliferation activity against three glioblastoma cell lines (U87, T98G, and U251). Compound

Indexed as

Antineoplastic AgentsDrug DesignGlioblastomaThiazolidinesApoptosisCell Line, TumorCell MovementCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic AgentsThiazolidinesautophagycell apoptosisglioblastomaPinenethiazolidione derivatives

Identifiers

PMID40905579
PMCPMC12412324

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.