ArticleAngewandte Chemie (International ed. in English)2025
Nickelaelectro-Catalyzed C─H Activation to β-Arylated Pyrroles via Multiple Dehydrogenation.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Nickelaelectro-Catalyzed C─H Activation to β-Arylated Pyrroles via Multiple Dehydrogenation.Angewandte Chemie (International ed. in English) · 2025Article
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7 authors.
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Abstract
Nickel electrocatalysis has emerged as a powerful strategy for sustainable C─H activation, offering an environmentally benign alternative to traditional methods based on stoichiometric oxidants. We, herein, report a nickela-electrocatalyzed approach for the expedient synthesis of β-arylated pyrroles via a unique multiple dehydrogenative C─H activation approach. Hence, direct C─C bond formation between pyrroles and arenes was enabled, obviating the need for prefunctionalized substrates. The reaction proceeded under electrochemical conditions in a user-friendly undivided cell, utilizing electricity as a traceless oxidant. Mechanistic studies, including cyclic voltammetry, provided support for a nickel(II/III/IV) regime, wherein anodic oxidation facilitates the dehydrogenation and C─H activation paired with the valuable hydrogen evolution reaction (HER). Our findings highlight the potential of electrocatalysis to unlock distinct reaction manifolds and provides a sustainable platform for accessing complex heteroaryl frameworks.
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