ArticleJournal of applied toxicology : JAT2026
Systemic Toxicity of L-Mimosine in Rabbits: A Non-Rodent Model for Safety Assessment.
Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Rabbit Immune Cell Function: In Vitro Assays for Immunological Assessment Studies Using Flow Cytometry.Biotech (Basel (Switzerland)) · 2026Article
- Sustainable Rabbit Production for the Caribbean: The Role of Multipurpose Trees and Forages as an Alternative Feedstuff.Animals : an open access journal from MDPI · 2026Review
- Systemic Toxicity of L-Mimosine in Rabbits: A Non-Rodent Model for Safety Assessment.Journal of applied toxicology : JAT · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
L-mimosine is a non-protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L-mimosine have been extensively studied in ruminants, its impact on monogastric species remains unexplored. Given the widespread use of these plants and the limited knowledge regarding L-mimosine toxicity in monogastric animals, this study aimed to investigate its toxicological effects in non-rodent monogastric species by assessing its subacute toxicity. To achieve this, L-mimosine was extracted from L. leucocephala seeds and administered orally, incorporated into the feed, at doses of 25, 40, and 60 mg/kg for 28 days in male rabbits. Although no clinical, biochemical, hormonal, or macroscopic alterations were observed, histopathological analyses revealed dose-dependent lesions in the liver, kidneys, thyroid, and spleen. These findings suggest that rabbits may be particularly susceptible to the toxic effects of L-mimosine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.