ArticleAdvanced healthcare materials2025
Graphene-Enhanced Plasmonic Interfaces: A General Strategy for Highly Sensitive Detection of Biomolecular Interactions.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Multifunctional plasmonic optical nanosensor based on ring resonator supercells for early pregnancy diagnosis using urine samples.Scientific reports · 2026Article
- Graphene Triggers Inflammation in Murine Microglia via Phagocytosis.Small science · 2026Article
- Cross-Platform Biosensing of Immune Receptors Using Peptide-Functionalized Graphene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Graphene-Enhanced Plasmonic Interfaces: A General Strategy for Highly Sensitive Detection of Biomolecular Interactions.Advanced healthcare materials · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The detection of cells and viruses is essential for research and clinical applications, creating a demand for high-performance biosensors. Surface plasmon resonance (SPR) enables label-free, real-time detection and is highly promising for healthcare, including point-of-care diagnostics. However, its performance is often limited in complex biological systems. Integrating two-dimensional (2D) materials such as graphene into SPR sensors has been proposed as a strategy to improve sensitivity, but experimental evidence remains scarce. Here, we investigate the influence of graphene on SPR biosensors using several relevant biological examples, including antibody-virus and peptide-cell interactions. Compared to gold sensors, graphene integration produced reproducible signal enhancement of up to 600%, far exceeding previous reports. Importantly, graphene-enhanced SPR enabled discrimination between different cell types, a capability not observed with gold alone. Our findings demonstrate that graphene provides substantially greater enhancement than predicted and can be applied across diverse biological systems. This establishes graphene-enhanced SPR as a powerful platform for advancing biosensor performance, with broad potential in biomedical research, diagnostics, and gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.