Evidence map›Paper›PMID 40905478›Full record

ArticleAdvanced healthcare materials2025

Redox-Active Polyphenol Red Molecularly Imprinted Polymers on Porous Gold Electrodes for Ultrasensitive, AI-Assisted Detection of Alzheimer's Biomarkers in Undiluted Biofluids.

Sudhaunsh Deshpande, Ajith Mohan Arjun, Guoyi Liu, Kryztof Pawlak, Sanjiv Sharma

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sudhaunsh DeshpandeDavid Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7BE, UK.ORCID 0009-0002-9711-1120
Ajith Mohan ArjunDavid Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7BE, UK.ORCID 0000-0001-6781-2108
Guoyi LiuDavid Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7BE, UK.
Kryztof PawlakMaterials Innovation Factory, University of Liverpool, 51 Oxford Street, Liverpool, L7 3NY, UK.
Sanjiv SharmaDavid Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7BE, UK.ORCID 0000-0003-3828-737X

Funding

MRC AMED /UK Japan MR/X02153X/1
6 · The paper itself

Abstract

Early diagnosis of Alzheimer's disease (AD) is hindered by the high cost, complexity, and centralization of current diagnostic platforms such as enzyme-linked immunosorbent assay (ELISA) and single-molecule array (SIMOA). Here, an integrated point-of-care (PoC) biosensing platform is reported based on redox-active polyphenol red molecularly imprinted polymers (pPhR MIPs) deposited on highly porous gold (HPG) electrodes for the ultrasensitive, reagent-free detection of phosphorylated tau 181 (p-tau 181) in undiluted plasma and serum. The unique electrochemical interface combines the signal-enhancing properties of HPG with the redox functionality of pPhR, eliminating the need for external redox probes. The resulting sensor achieves a limit of detection (LOD) of 980 fg mL

Indexed as

Alzheimer DiseaseGoldMolecularly Imprinted PolymersPolyphenolsBiomarkersBiosensing TechniquesElectrochemical TechniquesElectrodesHumansLimit of DetectionMachine LearningOxidation-ReductionPorositytau ProteinsBiomarkersGoldMolecularly Imprinted PolymersPolyphenolstau ProteinsAlzheimer's Diseaseelectrochemical biosensorspoint of care diagnosticspolyphenol RedpTau 181

Identifiers

PMID40905478
PMCPMC12716194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.