Evidence map›Paper›PMID 40905305›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2025

Results of a Pilot Randomized Controlled Trial of IDEAS for Hope: A Brief Telehealth Intervention for Suicide Prevention and HIV Care Engagement in Tanzania.

Brandon A Knettel, Kim Madundo, Ismail Amiri, Elizabeth F Msoka, Wei Pan, Theodora Khofi, Paul Ngangula, Elizabeth L Turner, Louise Joel, Jackline Rwakilomba and 6 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Brandon A KnettelDuke University School of Nursing, Durham, NC.ORCID 0000-0003-2986-1579
Kim MadundoKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Ismail AmiriDuke Global Health Institute, Durham, NC.
Elizabeth F MsokaKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Wei PanDuke University School of Nursing, Durham, NC.
Theodora KhofiUniversity of Global Health Equity, Butaro, Rwanda.
Paul NgangulaDuke Global Health Institute, Durham, NC.
Elizabeth L TurnerDuke Global Health Institute, Durham, NC.
Louise JoelKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Jackline RwakilombaKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Clotilda S TarimoKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Victor KatitiKilimanjaro Christian Medical University, Moshi, Tanzania.
Elizabeth T KnipplerDuke University School of Nursing, Durham, NC.
Blandina T MmbagaDuke Global Health Institute, Durham, NC.
Michael V RelfDuke University School of Nursing, Durham, NC.
David B GoldstonDepartment of Psychiatry & Behavioral Sciences, Duke University, Durham, NC.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Sociobehavioral Sciences Research to Improve Care for HIV Infection in TanzaniaD43TW009595 · FIC · KILIMANJARO CHRISTIAN MEDICAL CENTRE · PI Blandina Theophil Mmbaga · 2013 to 2026
$4.2M
Telehealth to Reduce Suicidality and lmprove HIV Care Engagement in TanzaniaK08MH124459 · NIMH · DUKE UNIVERSITY · PI KNETTEL, BRANDON A · 2021 to 2024
$694k
FIC NIH HHS D43 TW009595NIAID NIH HHS P30 AI064518NIMH NIH HHS K08 MH124459
6 · The paper itself

Abstract

objectivePeople living with HIV (PLWH) face greatly elevated risk of mental health challenges, including suicide. In Tanzania, there is a critical shortage of providers and interventions to address suicide risk. The 3-session IDEAS for Hope intervention is delivered by telehealth, combining universal suicide screening in HIV care, adherence strategies, HIV-related stigma reduction, and problem solving.

methodsWe identified 60 PLWH experiencing suicidal ideation at 2 HIV clinics in Kilimanjaro, Tanzania, and randomized them 1:1 to receive an evidence-based safety planning intervention or IDEAS for Hope. Participants completed surveys at baseline and 3-month follow-up with mixed-methods assessments of feasibility, acceptability, and preliminary efficacy to reduce suicidal ideation and improve HIV care engagement.

resultsSession attendance was high at 88% and intervention fidelity, quality, and counseling skills exceeded pre-established thresholds in 94% of sessions. Participants were very satisfied with the counselors and helpfulness of the intervention to reduce suicide risk and improve care engagement. Participants in both trial arms achieved near-total recovery in suicidal thoughts (Cramer V = 0.07, P = 0.617). Between-arm differences in HIV treatment adherence were nonsignificant but showed moderate effects in favor of the intervention (Cramer V = 0.18, P = 0.760). In qualitative feedback, participants described improvements in coping, social support, and problem solving for economic empowerment, which fostered a renewed sense of hope.

conclusionsIDEAS for Hope is a feasible and acceptable intervention that reduced suicide risk and improved HIV care engagement in this cohort. A larger clinical trial will be powered to determine comparative effectiveness, evaluate mechanisms of change, and inform future implementation strategies.

Indexed as

HIV InfectionsSuicide PreventionTelemedicineAdultFemaleHumansMaleMiddle AgedPilot ProjectsSuicidal IdeationTanzaniacounselingHIVmental healthsuicide preventiontask shiftingtelehealth

Identifiers

PMID40905305
PMCPMC12874625

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.