Evidence map›Paper›PMID 40905117›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2025

EcoHIV Infection Promotes Atherosclerosis Progression in LDLR-Deficient Mice.

Ivan Pinos, Amparo Blanco, Jennifer Kelschenbach, Mike Veenstra, Eva Hu, Hongxia He, Joan W Berman, David J Volsky, Jaume Amengual

Abstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ivan Pinos *Division of Nutritional Sciences (I.P., A.B., J.A.), University of Illinois Urbana-Champaign.ORCID 0000-0002-2236-8936
Amparo Blanco *Division of Nutritional Sciences (I.P., A.B., J.A.), University of Illinois Urbana-Champaign.ORCID 0009-0000-8819-3131
Jennifer KelschenbachDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (J.K., H.H., D.J.V.).
Mike VeenstraDepartment of Pathology (M.V., J.W.B.), Albert Einstein College of Medicine, Bronx, NY.
Eva HuDepartment of Food Science and Human Nutrition (E.H., J.A.), University of Illinois Urbana-Champaign.
Hongxia HeDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (J.K., H.H., D.J.V.).
Joan W BermanDepartment of Pathology (M.V., J.W.B.), Albert Einstein College of Medicine, Bronx, NY.
David J VolskyDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (J.K., H.H., D.J.V.).ORCID 0000-0001-6788-1752
Jaume AmengualDivision of Nutritional Sciences (I.P., A.B., J.A.), University of Illinois Urbana-Champaign.ORCID 0000-0002-6077-3545

Funding

Single cell transcriptomic and epigenomic changes during chronic HIV infection and cocaine self-administrationU01DA056003 · NIDA · ALLEN INSTITUTE · PI Paul J. Kenny, DAVID J VOLSKY · 2022 to 2026
$18.2M
Single cell brain transcriptome changes during chronic HIV infection and opiate use in conventional miceU01DA053629 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KENNY, PAUL J., VOLSKY, DAVID J · 2021 to 2025
$11.1M
Mechanism of Cannabidiol Effects on HIV Expression, Neuroinflammation, and HIV Cognitive Disease in Chronically-infected Immunocompetent MiceR01DA052844 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BORJABAD, ALEJANDRA, KELSCHENBACH, JENNIFER L · 2020 to 2024
$3.6M
To study the role of the low-density lipoprotein receptor on carotenoid biodistribution and excretionR01HL147252 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI AMENGUAL TERRASA, JAIME · 2019 to 2023
$2.1M
NHLBI NIH HHS R01 HL147252NIDA NIH HHS R01 DA052844NIDA NIH HHS U01 DA053629NIDA NIH HHS U01 DA056003
6 · The paper itself

Abstract

backgroundPeople with HIV are at higher risk of atherosclerotic cardiovascular disease than uninfected individuals; however, the molecular mechanisms behind this association remain elusive due to the lack of suitable animal models.

methodsTo study the impact of HIV on atherosclerotic cardiovascular disease, we infected the atheroprone

resultsIn comparison to uninfected controls, EcoHIV infection increased the ratio of circulating inflammatory monocytes, monocyte recruitment, and CD68

conclusionsOur data suggest that EcoHIV infection in

Indexed as

AortaAortic DiseasesAtherosclerosisReceptors, LDLAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeCollagenDisease Models, AnimalDisease ProgressionMaleMiceMice, Inbred C57BLMice, KnockoutMonocytesAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeCD68 protein, mouseCollagenReceptors, LDLacquired immunodeficiency syndromecardiovascular diseasesinflammationmacrophagesmyocytes, smooth muscle

Identifiers

PMID40905117
PMCPMC12700074

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.