Evidence map›Paper›PMID 40905082›Full record

ArticleHaematologica2026

Reporting blast percentage for response assessment in acute leukemias: recommendations from an EHA/ELN expert panel.

Sa A Wang, Leonor Arenillas, Francesco Buccisano, Monika Bruggemann, Wolfgang Kern, Manuel Menes, Adriana Plesa, Louisa Stone, Dominique Wellnitz, David A Westerman and 2 more

Abstract read
In one paragraph

Article in Haematologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sa A WangDepartment of Hematopathology, MD Anderson Cancer Center, Houston.
Leonor ArenillasDepartment of Pathology, Hospital del Mar, Barcelona.
Francesco BuccisanoDepartment of Biomedicine and Prevention, University Tor Vergata, Rome.
Monika BruggemannMedical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel.
Wolfgang KernMLL Munich Leukemia Laboratory, Munich.
Manuel MenesDepartment of Pathology, Baptist Health South Florida, Miami, Florida.
Adriana PlesaDepartment of Hematology Laboratory and FlowCytometry, Lyon University Hospital, CHU-HCL, Lyon Sud, Pierre Benite.
Louisa StoneAuckland City Hospital, Auckland.
Dominique WellnitzMedical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel.
David A WestermanDepartment of Pathology, Peter MacCallum Cancer Centre, Melbourne.
Brent L WoodDepartment of Pathology and Laboratory Medicine, Children's Hospital of Los Angeles, CA.
Sylvie D FreemanSchool of Infection, Inflammation and Immunology, University of Birmingham. s.freeman@ bham.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evaluation of bone marrow blast percentage is paramount to response criteria in acute leukemias. There is an identified need within the framework of updated laboratory practices to reduce inconsistencies in methodologies used by clinical laboratories to report blast values and clarify aspects of reporting. Representatives from international specialized working groups including the European Hematology Association (EHA) Diagnosis in Hematological Diseases Specialized Working Group and the European LeukemiaNet (ELN) produced consensus guidance for harmonized blast assessment to define response categories in patients with acute leukemia. This guidance addresses sampling best practice, key considerations for generating the most accurate blast enumeration and the limitations across the methodologies in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) and acute leukemia of ambiguous lineage. An integrated reporting scheme for deriving blast percentage is provided for ALL and AML. This incorporates results from appropriate measurable residual disease assays with morphological crosscheck. The practical guide and approach presented herein should facilitate uniform reporting standards both within clinical trials and in broader clinical practice.

Indexed as

Blast CrisisBone MarrowLeukemia, Myeloid, AcutePrecursor Cell Lymphoblastic Leukemia-LymphomaHumansNeoplasm, Residual

Identifiers

PMID40905082
PMCPMC12775769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.