ArticleClinical ophthalmology (Auckland, N.Z.)2025
Two-Year Real-World Outcomes of Faricimab for Diabetic Macular Edema in Japan.
Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Faricimab for Diabetic Macular Edema in Eyes Vitrectomized for Proliferative Diabetic Retinopathy: A 12-Month Retrospective Study.Journal of clinical medicine · 2026Article
- First-Line Faricimab in Diabetic Macular Edema: Insights from a Real-World Treatment-Naïve Population in Austria.Journal of clinical medicine · 2026Article
- Real-World 6-Month Treatment Outcomes of Faricimab in Turkey: The FARTURK Study.Ophthalmology and therapy · 2026Article
- Article
- Visual and Anatomic Outcomes of Faricimab in Naïve Neovascular Age-Related Macular Degeneration with Subretinal Hemorrhage: A Multi-Centre Retrospective Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetic macular edema (DME) is a leading cause of vision loss in working-age adults. Faricimab, a bispecific antibody targeting VEGF and Ang-2, has been shown to reduce treatment burden by enabling extended injection intervals. However, real-world, long-term data from Japanese populations are limited. Purpose: To evaluate the two-year efficacy and safety of intravitreal faricimab for DME in a real-world clinical setting in Japan. Methods: This retrospective observational study was conducted at the International Goodwill Hospital, Yokohama, Japan. Patients with DME who were followed for two years after initiating intravitreal faricimab. Outcome measures included central subfield thickness (CST), best-corrected visual acuity (BCVA), macular fluid resolution, and recurrence. Changes were evaluated using nonparametric tests and survival analysis. Results: We analyzed 9 patients (16 eyes) with DME who were followed for two years after initiating intravitreal faricimab. A four-injection loading phase was omitted in all but one case, with a median of one initial injection. CST decreased from 332.3 µm to 267.0 µm (p = 0.069), and BCVA remained stable (0.49 to 0.55 logMAR, p = 0.2081). Complete macular fluid resolution occurred in 87.5% of eyes, with a median resolution time of 6 months. Recurrence occurred in 37.5% of eyes during follow-up, with a median time to recurrence of 9 months. Among eyes on fixed dosing (n = 11), 72.7% achieved a final injection interval of ≥12 weeks. Intraretinal fluid (IRF) significantly decreased (p = 0.0078), and chronic cystoid changes were associated with limited CST reduction (p = 0.016). No treatment-related adverse events were reported. Conclusion: Faricimab demonstrated favorable anatomical outcomes and extended injection intervals over two years in a real-world setting, despite the omission of a loading phase in most cases. These findings support its practical utility of faricimab for DME management in Japan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.